Retinol-Binding Protein 4, Insulin Resistance, and Type 2 Diabetes

2006 ◽  
Vol 354 (24) ◽  
pp. 2596-2598 ◽  
Author(s):  
Kenneth S. Polonsky
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4

scholarly journals Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Karunee Kwanbunjan ◽  
Pornpimol Panprathip ◽  
Chanchira Phosat ◽  
Noppanath Chumpathat ◽  
Naruemon Wechjakwen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Binding Protein ◽  
Diabetes Risk ◽  
Retinol Binding Protein ◽  
High Type ◽  
Retinol Binding Protein 4

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Nature ◽  
2005 ◽  
Vol 436 (7049) ◽  
pp. 356-362 ◽  
Author(s):  
Qin Yang ◽  
Timothy E. Graham ◽  
Nimesh Mody ◽  
Frederic Preitner ◽  
Odile D. Peroni ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Retinol Binding Protein 4

scholarly journals Relation of Absolute or Relative Adiposity to Insulin Resistance, Retinol Binding Protein-4, Leptin, and Adiponectin in Type 2 Diabetes

2012 ◽  
Vol 36 (6) ◽  
pp. 415 ◽  
Author(s):  
You Lim Kim ◽  
Tae Kyun Kim ◽  
Eun Sun Cheong ◽  
Dong Geum Shin ◽  
Gyu Sik Choi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4

scholarly journals Retinol binding protein 4 and incident diabetes – the Atherosclerosis Risk in Communities Study (ARIC Study)

2013 ◽  
Vol 16 (2) ◽  
pp. 388-397 ◽  
Author(s):  
Vivian C. Luft ◽  
Mark Pereira ◽  
James S. Pankow ◽  
Christie Ballantyne ◽  
David Couper ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Incident Diabetes ◽  
Parental History ◽  
Nonesterified Fatty Acids ◽  
Atherosclerosis Risk In Communities ◽  
Retinol Binding Protein 4 ◽  
Atherosclerosis Risk

Background: Retinol binding protein 4 (RBP4) has been described as a link between impaired glucose uptake in adipocytes and systemic insulin sensitivity. Objective: To determine whether RBP4 fasting levels predict the development of type 2 diabetes. Methods: Using a case-cohort design, we followed 543 middle-aged individuals who developed diabetes and 537 who did not over ~9 years within the population-based Atherosclerosis Risk in Communities Study. Weighted Cox proportional hazards analyses permitted statistical inference of the RBP4 – incident diabetes associations to the entire cohort. Results: Women in the highest tertile of RBP4 presented greater risk of developing diabetes (HR = 1.74; 95%CI 1.03 – 2.94) in analyses adjusted for age, ethnicity, study center, parental history of diabetes, hypertension, glomerular filtration rate, body mass index, waist-hip ratio, nonesterified fatty acids, adiponectin, leptin, triglycerides and HDL-C. When additionally adjusted for fasting insulin, this association’s significance became borderline (HR = 1.68; 95%CI 1.00 – 2.82). No association between RBP4 levels and incident diabetes was found in men. Conclusion: These findings suggest that RBP4 levels may be directly involved in the pathogenesis of type 2 diabetes in women.

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