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Molnupiravir — A Step toward Orally Bioavailable Therapies for Covid-19
New England Journal of Medicine
◽
10.1056/nejme2117814
◽
2021
◽
Author(s):
Richard Whitley
Keyword(s):
Orally Bioavailable
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Macrophage Depletion Reveals an Active Role of the Immune System in Determining the In Vivo Disposition of an Orally Bioavailable Drug
10.26226/morressier.57d6b2bbd462b8028d88eb6e
◽
2016
◽
Author(s):
Phillip Rzeczycki
Keyword(s):
Immune System
◽
Active Role
◽
Macrophage Depletion
◽
Orally Bioavailable
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Faculty Opinions recommendation of Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.1046522.496495
◽
2006
◽
Author(s):
Andrew Combs
Keyword(s):
Hepatitis C Virus
◽
Hepatitis C
◽
Protease Inhibitor
◽
Therapeutic Agent
◽
Hepatitis C Infection
◽
Potential Therapeutic Agent
◽
Orally Bioavailable
◽
Ns3 Protease
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Faculty Opinions recommendation of Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.1080870.533803
◽
2007
◽
Author(s):
Thomas W von Geldern
Keyword(s):
Receptor Antagonists
◽
B1 Receptor
◽
Bradykinin B1 Receptor
◽
Orally Bioavailable
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Faculty Opinions recommendation of Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.13357116.14726431
◽
2011
◽
Author(s):
Manoj Desai
◽
Dmitry Koltun
Keyword(s):
Kinase Inhibitor
◽
Pi3 Kinase
◽
Class I
◽
Orally Bioavailable
Download Full-text
Faculty Opinions recommendation of Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.14208965.15726072
◽
2012
◽
Author(s):
David Rotella
Keyword(s):
Orally Bioavailable
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Faculty Opinions recommendation of Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.718319734.793492567
◽
2014
◽
Author(s):
Jefferson Tilley
Keyword(s):
Inverse Agonist
◽
Ghrelin Receptor
◽
Orally Bioavailable
◽
Receptor Inverse Agonist
◽
Clinical Candidate
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Faculty Opinions recommendation of Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.718490794.793514568
◽
2016
◽
Author(s):
Wade Blair
Keyword(s):
Orally Bioavailable
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Faculty Opinions recommendation of Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.718490794.793497461
◽
2014
◽
Author(s):
John Lowe
Keyword(s):
Orally Bioavailable
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Faculty Opinions recommendation of Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.726596256.793523523
◽
2016
◽
Author(s):
Darrell Brann
Keyword(s):
Hot Flushes
◽
Hormonal Effects
◽
17Β Estradiol
◽
Orally Bioavailable
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X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson’s Disease
Journal of Medicinal Chemistry
◽
10.1021/acs.jmedchem.1c00303
◽
2021
◽
Author(s):
Xiang-Li Ning
◽
Yu-Zhi Li
◽
Cui Huo
◽
Ji Deng
◽
Cheng Gao
◽
...
Keyword(s):
Parkinson’S Disease
◽
Parkinson's Disease
◽
Mouse Model
◽
Guided Discovery
◽
X Ray
◽
Orally Bioavailable
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