The chapter will, first of all, consider the challenges for educational designers of the need to maximise the opportunities of e-learning by enabling learners to participate in learning experiences, activities, and forms of communication that are congruent with their values, belief systems, and styles of learning. Second, by building on extant research and frameworks, the chapter will propose an integrated framework and set of guidelines for the development of quality learning resources for a global community of learners. The chapter makes a case for the internationalisation of learning resources informed by a flexible and pluralistic approach to design, based on the concept of constructive alignment.