This study primarily focuses on solving a practical OVRP by applying a novel hybrid adaptive Genetic Algorithm and Tabu Search (GA-TS). The GA-TS combines the GA's parallel computing and global optimization with TS's Tabu search skill and fast local search. In the GA-TS Algorithm, individuals of population do TS local search with a certain degree of probability using natural number coding. It not only ensures global optimization, but also improves the speed of computing. The Algorithm is applied to optimize the mines material transport vehicle routing of China Zhengzhou Coal Mine and power Supply Co., Ltd. Through the applications, the optimal economical transport routing has been set up and economic costs have been greatly reduced.