High performance detection of biomolecules using a high magnetic field electrospray ionization source/Fourier transform ion cyclotron resonance mass spectrometer

1995 ◽  
Vol 66 (9) ◽  
pp. 4507-4515 ◽  
Author(s):  
Ziqiang Guan ◽  
Victoria L. Campbell ◽  
Jared J. Drader ◽  
Christopher L. Hendrickson ◽  
David A. Laude
Keyword(s):  
Magnetic Field ◽  
Fourier Transform ◽  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
High Magnetic Field ◽  
Cyclotron Resonance ◽  
High Performance ◽  
Ion Cyclotron Resonance ◽  
Ionization Source ◽  
Detection Of Biomolecules

Selected-ion accumulation from an external electrospray ionization source with a fourier-transform ion cyclotron resonance mass spectrometer

1993 ◽  
Vol 7 (10) ◽  
pp. 914-919 ◽  
Author(s):  
James E. Bruce ◽  
Gordon A. Anderson ◽  
Steven A. Hofstadler ◽  
Steven L. van Orden ◽  
Michael S. Sherman ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Cyclotron Resonance ◽  
Ion Accumulation ◽  
Ion Cyclotron Resonance ◽  
Ionization Source ◽  
Ion Cyclotron

High Performance Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at Low Magnetic Field

2002 ◽  
Vol 8 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Michael V. Gorshkov ◽  
Harold R. Udseth ◽  
Gordon A. Anderson ◽  
Richard D. Smith
Keyword(s):  
Magnetic Field ◽  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electrospray Ionization ◽  
Cyclotron Resonance ◽  
High Performance ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron ◽  
Low Magnetic Field ◽  
Ft Icr

A comprehensive characterization of a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer utilizing a 1 tesla magnet with an electrospray ionization (ESI) source is presented. A resolution of up to 10,000,000 and a ppb-level mass accuracy has been achieved for atomic ions and light molecules produced with electron ionization. It has also been demonstrated that a resolution of up to 1,000,000 can be achieved for signals from biomolecule ions obtained with an ESI source, with the highest molecular weight for which the 13C isotopic pattern was completely resolved being that of ubiquitin (8565 Da). Several features of FT-ICR mass spectrometry at low magnetic field are discussed and approaches to overcome the low-field constraints are presented.

Sign in / Sign up

Export Citation Format

Share Document