Expression of p63 and 14-3-3σ in Normal and Hyperdifferentiated Mucosa of the Upper Aerodigestive Tract

2002 ◽  
Vol 126 (6) ◽  
pp. 598-601 ◽  
Author(s):  
Joseph C. Sniezek ◽  
Keith E. Matheny ◽  
Brian B. Burkey ◽  
James L. Netterville ◽  
Jennifer A. Pietenpol
Keyword(s):  
Molecular Markers ◽  
Head And Neck ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Immunohistochemical Analysis ◽  
Normal Mucosa ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Oral Lichen

OBJECTIVE: Our goal was to analyze p63 and 14-3-3σ expression in normal and hyperdifferentiated head and neck mucosa. STUDY DESIGN: Compare the in vivo expression of p63 and 14-3-3σ by immunohistochemistry in normal mucosa and oral lichen planus, a benign mucosal lesion marked by hyperdifferentiation and apoptosis. RESULTS AND CONCLUSION: p63 is underexpressed and 14-3-3σ is overexpressed in lichen planus on immunohistochemical analysis. SIGNIFICANCE: The findings support the hypothesis that p63 plays an antidifferentiation role, whereas 14-3-3σ plays a prodifferentiation role in the upper aerodigestive tract epithelium. Lichen planus is a valuable model for the study of p63, 14-3-3σ, and mucosal differentiation. p63 and 14-3-3σ may be molecular markers for oral lichen planus.

scholarly journals Molecular markers in oral lichen planus: A systematic review

2016 ◽  
Vol 20 (1) ◽  
pp. 115 ◽  
Author(s):  
Shitalkumar Sagari ◽  
Sudhanshu Sanadhya ◽  
Mallikarjun Doddamani ◽  
Rajan Rajput
Keyword(s):  
Systematic Review ◽  
Molecular Markers ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

In vivo reflectance confocal microscopy of oral lichen planus

2019 ◽  
Vol 58 (8) ◽  
pp. 940-945 ◽  
Author(s):  
Maria Contaldo ◽  
Dario Di Stasio ◽  
Massimo Petruzzi ◽  
Rosario Serpico ◽  
Alberta Lucchese
Keyword(s):  
Confocal Microscopy ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Reflectance Confocal Microscopy ◽  
Oral Lichen

Angiogenesis in Oral Lichen Planus: An In Vivo and Immunohistological Evaluation

2011 ◽  
Vol 59 (6) ◽  
pp. 457-462 ◽  
Author(s):  
Giuseppe Alessandro Scardina ◽  
Alessia Ruggieri ◽  
Emiliano Maresi ◽  
Pietro Messina
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Expression of HER2/neu in premalignant lesions of oral cavity

2020 ◽  
Author(s):  
Vansh Verma ◽  
Dr. Ashesh Kumar Jha ◽  
Dr. Karsing Patiri ◽  
Dr. Nikhil Arora
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Normal Mucosa ◽  
Premalignant Lesions ◽  
Severe Dysplasia ◽  
Positive Contribution ◽  
Cytoplasmic Staining ◽  
Oral Lichen

Context: Molecular alterations in premalignant lesions of oral cavity are not well known, many reports and have found increased HER2 expression to be correlated with poor prognosis in oral cancer. However,literature on expression of HER2 in premalignant lesions is limited and data is conflicting in nature. Overexpression of HER2 in premalignant lesions may denote its positive contribution in malignant transformation of these lesions. Aims: To evaluate the expression of HER2 in premalignant lesions of oral cavity. Settings and Design: In this prospective observational study of 2 months, patients attending OPD at Department of ENT and meeting the inclusion criteria were included. Methods and Material: 23 samples of Leukoplakia and 1 sample of oral lichen planus were stained by routine H&E to confirm clinical diagnosis and assess dysplasia if any, 5 samples of normal mucosa were used as control. Immunohistochemical staining for HER2 was done. ASCO/CAP 2018 guidelines were used for reporting the results. Statistical analysis used: Percentage of lesions expressing cytoplasmic or membranous expression was calculated. Results: 1 sample of Leukoplakia with severe dysplasia expressed focal membranous staining. 20% leukoplakia lesions expressed cytoplasmic staining. Staining was not observed in oral lichen planus and leucoplakia without dysplasia. Conclusions: Membranous expression in Severe dysplasia and higher expression in oral cancer is in concordance with the multistep theory of carcinogenesis. Larger studies are needed if HER2 is to be proposed as a marker for oral premalignant lesions. Significance of cytoplasmic staining in oral premalignant lesions needs to be elucidated.

scholarly journals Immunohistochemical analysis of Ki-67 expression in oral lichen planus lesions

2015 ◽  
Vol 4 (1) ◽  
pp. 25-30
Author(s):  
Nazanin Bashardoust ◽  
Shirin Modabbernia ◽  
Sara Bagheri ◽  
Atena Shiva ◽  
Reza Jalali ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Immunohistochemical Analysis ◽  
Ki 67 ◽  
Oral Lichen

scholarly journals Novel Bilayer Mucoadhesive Patches for Delivery of Clobetasol-17-Propionate to the Oral Mucosa to Treat Oral Lichen Planus; an in Vitro and in Vivo Evaluation

2018 ◽  
Vol 126 (4) ◽  
pp. e204
Author(s):  
Helen E. Colley ◽  
Zulfahami Said ◽  
Martin E. Santocildes-Romero ◽  
Sarah R. Baker ◽  
Katie D'Apice ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
In Vivo Evaluation ◽  
Oral Lichen
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