scholarly journals Immunohistochemical analysis of Ki-67 expression in oral lichen planus lesions

2015 ◽  
Vol 4 (1) ◽  
pp. 25-30
Author(s):  
Nazanin Bashardoust ◽  
Shirin Modabbernia ◽  
Sara Bagheri ◽  
Atena Shiva ◽  
Reza Jalali ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Immunohistochemical Analysis ◽  
Ki 67 ◽  
Oral Lichen

scholarly journals Histopathological specialized staining of oral lichen planus-induced fibrotic changes and surgical treatment of associated restricted mouth opening: a case report

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Atsushi Shudo
Keyword(s):  
Surgical Treatment ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Histopathological Examination ◽  
Mouth Opening ◽  
Ki 67 ◽  
Collagen Formation ◽  
Immune Mediated ◽  
Cytokeratin 13 ◽  
Oral Lichen

Abstract Background Oral lichen planus is a chronic inflammatory and immune-mediated disease that affects the oral mucosa. Recent findings have suggested that oral lichen planus is often associated with submucosal fibrotic changes. Fibrotic changes in the buccal submucosa may cause restricted mouth opening. This report discusses the histopathological examination (including specialized staining) and surgical treatment for oral lichen planus-induced fibrotic changes. Case presentation Here, we describe a 63-year-old woman who had oral lichen planus with fibrotic changes. Her maximum mouth opening distance was approximately 30 mm due to submucosal fibrotic changes, and she exhibited gradual fibrosis progression. Histological examinations were performed to assess the oral lichen planus-induced fibrotic changes. Then, double Z-plasty were performed as treatment for restricted mouth opening. The immunohistochemical staining results were negative for cytokeratin 13 and positive in some layers for cytokeratin 17 and Ki-67/MIB-1. Masson's trichrome staining showed enhanced collagen formation. Postoperative mouth opening training enabled the patient to achieve a mouth opening distance of > 50 mm. Conclusion Our findings suggest that histopathological examination with specialized staining can aid in the evaluation of oral lichen planus-induced fibrotic changes, and that Z-plasty is effective for the treatment of restricted mouth opening due to oral lichen planus.

Expression of p63 and 14-3-3σ in Normal and Hyperdifferentiated Mucosa of the Upper Aerodigestive Tract

2002 ◽  
Vol 126 (6) ◽  
pp. 598-601 ◽  
Author(s):  
Joseph C. Sniezek ◽  
Keith E. Matheny ◽  
Brian B. Burkey ◽  
James L. Netterville ◽  
Jennifer A. Pietenpol
Keyword(s):  
Molecular Markers ◽  
Head And Neck ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Immunohistochemical Analysis ◽  
Normal Mucosa ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Oral Lichen

OBJECTIVE: Our goal was to analyze p63 and 14-3-3σ expression in normal and hyperdifferentiated head and neck mucosa. STUDY DESIGN: Compare the in vivo expression of p63 and 14-3-3σ by immunohistochemistry in normal mucosa and oral lichen planus, a benign mucosal lesion marked by hyperdifferentiation and apoptosis. RESULTS AND CONCLUSION: p63 is underexpressed and 14-3-3σ is overexpressed in lichen planus on immunohistochemical analysis. SIGNIFICANCE: The findings support the hypothesis that p63 plays an antidifferentiation role, whereas 14-3-3σ plays a prodifferentiation role in the upper aerodigestive tract epithelium. Lichen planus is a valuable model for the study of p63, 14-3-3σ, and mucosal differentiation. p63 and 14-3-3σ may be molecular markers for oral lichen planus.

scholarly journals Immunohistochemical Evaluation of Ki-67 Expression in Erosive andNon-Erosive Oral Lichen Planus

2016 ◽  
Vol 8 (2) ◽  
pp. 1-1
Author(s):  
Narges Gholizadeh ◽  
Masoumeh Mehdipour ◽  
Esmaiil Dadgar ◽  
Ayla Bahramian ◽  
Delaram Ebrahimpour Moghaddas
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Ki 67 ◽  
Oral Lichen

scholarly journals Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential

2018 ◽  
Author(s):  
Eduardo Rosa ◽  
Aura Hurtado‑Puerto ◽  
Denise Falc�o ◽  
Aline Brietzke ◽  
Luiz de Almeida Prado Franceschi ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Ki 67 ◽  
Oral Lichen

scholarly journals Immunohistochemical Analysis of the Activation Status of the Akt/mTOR/pS6 Signaling Pathway in Oral Lichen Planus

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Georgios Prodromidis ◽  
Nikolaos G. Nikitakis ◽  
Alexandra Sklavounou
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Human Cancer ◽  
Immunohistochemical Analysis ◽  
Normal Oral Mucosa ◽  
Malignant Lesions ◽  
Oral Lichen ◽  
Control Samples ◽  
Activation Status

Introduction. Aberrations of the Akt/mTOR/pS6 pathway have been linked to various types of human cancer, including oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the activation status of Akt, mTOR, and pS6 in oral lichen planus (OLP) in comparison with oral premalignant and malignant lesions and normal oral mucosa (NM).Materials and Methods. Immunohistochemistry for p-Akt, p-mTOR, and phospho-pS6 was performed in 40 OLP, 20 oral leukoplakias (OL), 10 OSCC, and 10 control samples of NM.Results. Nuclear p-Akt expression was detected in the vast majority of cases in all categories, being significantly higher in OL. Cytoplasmic p-Akt and p-mTOR staining was present only in a minority of OLP cases, being significantly lower compared to OL and OSCC. Phospho-pS6 showed cytoplasmic positivity in most OLP cases, which however was significantly lower compared to OL and OSCC.Conclusions. Overall, cytoplasmic p-Akt, p-mTOR, and phospho-pS6 levels appear to be significantly lower in OLP compared to OL and OSCC. However, the expression of these molecules in a subset of OLP cases suggests that activation of Akt/mTOR/pS6 may occur in the context of OLP, possibly contributing to the premalignant potential of individual cases.

Immunohistochemical expression of Bcl-2 and Ki-67 in oral lichen planus and leukoplakia with different degrees of dysplasia

2014 ◽  
Vol 54 (2) ◽  
pp. 150-155 ◽  
Author(s):  
Fernanda Mombrini Pigatti ◽  
Luís Antônio de Assis Taveira ◽  
Cléverson Teixeira Soares
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Immunohistochemical Expression ◽  
Ki 67 ◽  
Oral Lichen
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