Tetrahydrocannabinol (THC) is the main psychoactive agent in the leaves of cannabis (marijuana) plants. Many synthetic cannabinoids have been recently developed. Cannabis is the most commonly used illicit drug in the United States; almost 20 million Americans currently consume cannabis. People who use cannabis may experience relaxation, euphoria, and mild hallucinogenic effects. Some may experience nausea and vomiting after use. Synthetic cannabinoids have been associated with more serious complications. Cessation after regular use may result in drug craving, insomnia, anorexia, and restlessness. Metabolites of THC can be detected in the urine up to 1 month after last use; some medications can cause false-positive tests. Serious medical complications of cannabis use are uncommon; the most concerning are neuropsychological problems among adolescent users and acute cognitive and motor impairment. Synthetic cannabinoid use is associated with significant neuropsychological effects. Psychosocial modalities appear to help those who wish to stop or reduce use. There are no medications that have been shown to be effective.