The unmet need in Fabry disease: A retrospective analysis of healthcare claims in the United States reveals significant burden of illness in ERT-treated patients

2020 ◽  
Vol 129 (2) ◽  
pp. S157
Author(s):  
Eric Wallace ◽  
Brian Davis ◽  
Juan Wu ◽  
Meghan Moynihan ◽  
Brian Griffin ◽  
...  
2002 ◽  
Vol 129 (1) ◽  
pp. 9-17 ◽  
Author(s):  
H. HERIKSTAD ◽  
S. YANG ◽  
T. J. VAN GILDER ◽  
D. VUGIA ◽  
J. HADLER ◽  
...  

This study was performed to better understand and more precisely quantify the amount and burden of illness caused by acute diarrhoea in the United States today. A telephone-based population survey was conducted between 1 July, 1996, and 31 June, 1997, in sites of the Foodborne Diseases Active Surveillance Network (FoodNet). The overall prevalence of acute diarrhoea in the 4 weeks before interview was 11%, giving a rate of 1.4 episodes of diarrhoea per person per year. The rate of diarrhoeal illness defined as a diarrhoeal episode lasting longer than 1 day or which resulted in significant impairment of daily activities was 0.7 per person per year. It can be concluded that acute diarrhoea is common and represents a significant burden of illness in the United States. Our data on self-reported diarrhoea, when generalized to the entire nation, suggests 375 million episodes of acute diarrhoea each year in the United States. Many of these episodes are mild. However, our data also indicate that there are approximately 200 million episodes of diarrhoeal illness each year in the United States.


Drug Safety ◽  
2021 ◽  
Vol 44 (4) ◽  
pp. 447-454 ◽  
Author(s):  
Yasser Albogami ◽  
Amir Sarayani ◽  
Juan M. Hincapie-Castillo ◽  
Almut G. Winterstein

Blood ◽  
2013 ◽  
Vol 121 (24) ◽  
pp. 4861-4866 ◽  
Author(s):  
Luciano J. Costa ◽  
Ana C. Xavier ◽  
Amy E. Wahlquist ◽  
Elizabeth G. Hill

Key Points Survival of patients with BL improved substantially in the United States during the past decade, mainly among young adults. Survival of patients with BL remains relatively low, particularly for older and black patients, identifying an unmet need.


2017 ◽  
Vol 157 ◽  
pp. 107-117 ◽  
Author(s):  
Ben Putman ◽  
Greg Thoma ◽  
Jasmina Burek ◽  
Marty Matlock

2019 ◽  
Vol 43 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Davide Ausili ◽  
Claudio Barbaranelli ◽  
Barbara Riegel

Measuring self-care behaviors is crucial in diabetes research worldwide. Having a common measure of self-care represents an unmet need limiting the development of the science. The Self-Care of Diabetes Inventory was developed to address limitations of previous tools that were not theoretically grounded, strong in psychometrics, and clinically validated. However, the generalizability and comparability of the Self-Care of Diabetes Inventory has not been tested across cultures and languages. The aim of this study was to test the invariance of the Self-Care of Diabetes Inventory measurement model between Italy and the United States. Data from two multicenter cross-sectional studies were used. Two diabetes clinics and two hospitals in Italy and the United States were involved. We enrolled 200 adults in Italy and 226 in the United States, all with a confirmed diagnosis of type 1 or type 2 diabetes. The Self-Care of Diabetes Inventory was used to measure self-care maintenance, monitoring, and management behaviors as described in the middle range theory of self-care of chronic illness. Configural, metric, scalar, and strict invariance were tested for each scale. Three of the four measurement equivalence levels were supported in the three Self-Care of Diabetes Inventory Scales, whereas strict invariance—the highest level—was reached only by the Self-Care Maintenance and Self-Care Monitoring Scales. Clear support for the use of the Self-Care of Diabetes Inventory in diabetes research was provided. Cross-national comparisons of self-care between groups of Italian and U.S. patients are supported, based on the invariance of the measurement model. Aggregation of research data obtained using the Self-Care of Diabetes Inventory across countries could support knowledge development in the field of diabetes self-care.


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