A Facile Preparation of α-Aryl Carboxylic Acid via One-Flow Arndt–Eistert Synthesis
Keyword(s):
An efficient, one-flow Arndt–Eistert synthesis was demonstrated. A sequence of acid chloride formation–nucleophilic acyl substitution–Wolff rearrangement–nucleophilic addition was performed in a microflow system without isolating any intermediates, which included a potentially explosive compound. The microflow system was made from simple, inexpensive, and readily available instruments and tubes. α-Aryl esters 2a and 2b were prepared in yields of 33 and 23 % (three steps) respectively.
1989 ◽
Vol 21
(2)
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pp. 251-253
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1967 ◽
Vol 45
(11)
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pp. 1247-1251
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Keyword(s):
2013 ◽
Vol 18
(3)
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pp. 181-188