FACILE PREPARATION OF L-2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID (OTC)

1989 ◽  
Vol 21 (2) ◽  
pp. 251-253 ◽  
Author(s):  
T. Kömives
Keyword(s):  
Carboxylic Acid ◽  
Facile Preparation

Exchange reactions of carboxylic acid salts. Facile preparation of .alpha.-deuteriocarboxylic acids

1968 ◽  
Vol 90 (2) ◽  
pp. 498-499 ◽  
Author(s):  
Joseph G. Atkinson ◽  
Jeno J. Csakvary ◽  
G. T. Herbert ◽  
Ronald S. Stuart
Keyword(s):  
Carboxylic Acid ◽  
Exchange Reactions ◽  
Facile Preparation ◽  
Acid Salts

scholarly journals Facile Preparation of optically Pure (3S)- and (3R)- 1, 2, 3, 4-Tetrahydroisoquinoline-3-carboxylic Acid

1983 ◽  
Vol 31 (1) ◽  
pp. 312-314 ◽  
Author(s):  
KIMIAKI HAYASHI ◽  
YASUHIKO OZAKI ◽  
KENICHI NUNAMI ◽  
NAOTO YONEDA
Keyword(s):  
Carboxylic Acid ◽  
Facile Preparation ◽  
Optically Pure

A Facile Preparation of α-Aryl Carboxylic Acid via One-Flow Arndt–Eistert Synthesis

2015 ◽  
Vol 68 (11) ◽  
pp. 1657 ◽  
Author(s):  
Shinichiro Fuse ◽  
Yuma Otake ◽  
Yuto Mifune ◽  
Hiroshi Tanaka
Keyword(s):  
Carboxylic Acid ◽  
Acid Chloride ◽  
Nucleophilic Addition ◽  
Wolff Rearrangement ◽  
Facile Preparation ◽  
Nucleophilic Acyl Substitution

An efficient, one-flow Arndt–Eistert synthesis was demonstrated. A sequence of acid chloride formation–nucleophilic acyl substitution–Wolff rearrangement–nucleophilic addition was performed in a microflow system without isolating any intermediates, which included a potentially explosive compound. The microflow system was made from simple, inexpensive, and readily available instruments and tubes. α-Aryl esters 2a and 2b were prepared in yields of 33 and 23 % (three steps) respectively.

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

1969 ◽  
Vol 21 (02) ◽  
pp. 294-303 ◽  
Author(s):  
H Mihara ◽  
T Fujii ◽  
S Okamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Carboxylic Acid ◽  
Fibrinolytic Activity ◽  
Clinical Implications ◽  
Trans Form ◽  
Plate Method ◽  
Blood Samples ◽  
Fibrin Plate ◽  
The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

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