The Synthesis and Biological Evaluation of Anithiactin A/Thiasporine C and Analogues
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The synthesis of anithiactin A has been achieved in four steps. Several closely related analogues were synthesised and their biological activity against colon and breast cancer cell lines evaluated. Anithiactin A was found not to be cytotoxic even at a high concentration (100 μM); however, two 4-substituted phenyl thiazoles were found to be moderately cytotoxic at 10 μM. Based on these results, 4-substitution on the phenyl group appears to be critical for cytotoxicity. However, the exact electronic and structural requirements are unclear.
2020 ◽
Vol 13
(3)
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pp. 4959-4964
2017 ◽
Vol 27
(3)
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pp. 607-611
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2020 ◽
Vol 35
(1)
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pp. 1641-1656
2013 ◽
Vol 23
(23)
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pp. 6401-6405
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Synthesis of 17β-estradiol platinum(II) complexes: biological evaluation on breast cancer cell lines
2003 ◽
Vol 13
(22)
◽
pp. 3927-3931
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