The Synthesis and Biological Evaluation of Anithiactin A/Thiasporine C and Analogues

2015 ◽  
Vol 68 (12) ◽  
pp. 1829 ◽  
Author(s):  
Richard A. Lamb ◽  
Michael P. Badart ◽  
Brooke E. Swaney ◽  
Sinan Gai ◽  
Sarah K. Baird ◽  
...  

The synthesis of anithiactin A has been achieved in four steps. Several closely related analogues were synthesised and their biological activity against colon and breast cancer cell lines evaluated. Anithiactin A was found not to be cytotoxic even at a high concentration (100 μM); however, two 4-substituted phenyl thiazoles were found to be moderately cytotoxic at 10 μM. Based on these results, 4-substitution on the phenyl group appears to be critical for cytotoxicity. However, the exact electronic and structural requirements are unclear.

Amino Acids ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. 923-935 ◽  
Author(s):  
Caroline Descôteaux ◽  
Kevin Brasseur ◽  
Valérie Leblanc ◽  
Sophie Parent ◽  
Éric Asselin ◽  
...  

2003 ◽  
Vol 13 (22) ◽  
pp. 3927-3931 ◽  
Author(s):  
Caroline Descôteaux ◽  
Josée Provencher-Mandeville ◽  
Isabelle Mathieu ◽  
Valérie Perron ◽  
Sanat K Mandal ◽  
...  

2022 ◽  
Vol 146 ◽  
pp. 528-537
Author(s):  
GeorginaVenecia Bello-Martínez ◽  
Génesis García-Ramírez ◽  
Monserrat Olea-Flores ◽  
Napoleón Navarro-Tito ◽  
Alberto Hernández-Moreno ◽  
...  

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