scholarly journals Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome

2006 ◽  
Vol 103 (16) ◽  
pp. 6392-6397 ◽  
Author(s):  
K. Zacharowski ◽  
P. A. Zacharowski ◽  
A. Koch ◽  
A. Baban ◽  
N. Tran ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Crucial Role ◽  
Systemic Inflammatory Response ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Adrenal Response

Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome

2003 ◽  
Vol 31 (3) ◽  
pp. 652-653 ◽  
Author(s):  
N.J.A. Child ◽  
I.A. Yang ◽  
M.C.K. Pulletz ◽  
K. de Courcy-Golder ◽  
A.-L. Andrews ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Odds Ratio ◽  
Systemic Inflammatory Response ◽  
Minor Allele ◽  
Morbidity And Mortality ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 (TLR4) Asp-299→Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P=0.076), suggesting a role for TLR4 signalling in the severity of SIRS.

Toll-like receptor 4 plays a crucial role in the immune-adrenal response to endotoxemia

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
K Zacharoski ◽  
PA Zacharowski ◽  
A Koch ◽  
A Baban ◽  
R Berkels ◽  
...  
Keyword(s):  
Crucial Role ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Adrenal Response

Systemic inflammatory response syndrome after major abdominal surgery

2019 ◽  
pp. 113-116
Author(s):  
Abdullah AlSomali ◽  
Abdullah Mobarki ◽  
Mohammed Almuhanna ◽  
Abdullah Alqahtani ◽  
Ziyad Alhawali ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Abdominal Surgery ◽  
Systemic Inflammatory Response ◽  
Major Abdominal Surgery
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