scholarly journals Medial temporal lobe BOLD activity at rest predicts individual differences in memory ability in healthy young adults

2008 ◽  
Vol 105 (47) ◽  
pp. 18555-18560 ◽  
Author(s):  
G. S. Wig ◽  
S. T. Grafton ◽  
K. E. Demos ◽  
G. L. Wolford ◽  
S. E. Petersen ◽  
...  
Keyword(s):  
Young Adults ◽  
Individual Differences ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Ability

scholarly journals Individual differences in neurocognitive aging of the medial temporal lobe

AGE ◽  
2006 ◽  
Vol 28 (3) ◽  
pp. 221-233 ◽  
Author(s):  
Michela Gallagher ◽  
Carlo Colantuoni ◽  
Howard Eichenbaum ◽  
Rebecca P. Haberman ◽  
Peter R. Rapp ◽  
...  
Keyword(s):  
Individual Differences ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Neurocognitive Aging

scholarly journals Neural and behavioral correlates of episodic memory are associated with temporal discounting in older adults

2019 ◽  
Author(s):  
Karolina M. Lempert ◽  
Dawn J. Mechanic-Hamilton ◽  
Long Xie ◽  
Laura E.M. Wisse ◽  
Robin de Flores ◽  
...  
Keyword(s):  
Older Adults ◽  
Individual Differences ◽  
Episodic Memory ◽  
Temporal Lobe ◽  
Cortical Thickness ◽  
Medial Temporal Lobe ◽  
Structural Integrity ◽  
Temporal Discounting ◽  
Risk Tolerance ◽  
Trade Offs

AbstractWhen facing decisions involving trade-offs between smaller, sooner and larger, delayed rewards, people tend to discount the value of future rewards. There are substantial individual differences in this tendency toward temporal discounting, however. One neurocognitive system that may underlie these individual differences is episodic memory, given the overlap in the neural circuitry involved in imagining the future and remembering the past. Here we tested this hypothesis in older adults, including both those that were cognitively normal and those with amnestic mild cognitive impairment (MCI). We found that performance on neuropsychological measures of episodic memory retrieval was associated with temporal discounting, such that people with better memory discounted delayed rewards less. This relationship was specific to episodic memory and temporal discounting, since executive function (another cognitive ability) was unrelated to temporal discounting, and episodic memory was unrelated to risk tolerance (another decision-making preference). We also examined cortical thickness and volume in medial temporal lobe regions critical for episodic memory. Entorhinal cortical thickness was associated with reduced temporal discounting, with episodic memory performance partially mediating this association. The inclusion of MCI participants was critical to revealing these associations between episodic memory and entorhinal cortical thickness and temporal discounting. These effects were larger in the MCI group, reduced after controlling for MCI status, and statistically significant only when including MCI participants in analyses. Overall, these findings suggest that individual differences in temporal discounting are driven by episodic memory function, and that a decline in medial temporal lobe structural integrity may impact temporal discounting.

Brain activation on fMRI and verbal memory ability: Functional neuroanatomic correlates of CVLT performance

2001 ◽  
Vol 7 (1) ◽  
pp. 55-62 ◽  
Author(s):  
STERLING C. JOHNSON ◽  
ANDREW J. SAYKIN ◽  
LAURA A. FLASHMAN ◽  
THOMAS W. McALLISTER ◽  
MOLLY B. SPARLING
Keyword(s):  
Temporal Lobe ◽  
Verbal Memory ◽  
Medial Temporal Lobe ◽  
Word Processing ◽  
Right Hemisphere ◽  
Verbal Learning ◽  
Clinical Test ◽  
Memory Ability ◽  
The Right ◽  
Novel Words

We have recently reported (Saykin et al., 1999b) selective activation of left medial temporal lobe structures during processing of novel compared to familiar words using functional magnetic resonance imaging (fMRI). The current study describes the relationship between a widely used clinical test of verbal learning, the California Verbal Learning Test (CVLT), and the previously reported fMRI activations. Thirteen right-handed healthy adult participants were studied with whole brain echo-planar fMRI while listening to novel and recently learned (familiar) words intermixed pseudorandomly in an event-related design. These participants were also tested with the CVLT. Scores for CVLT Trial 1 (immediate encoding of novel words) and recognition discriminability (recognition of familiar vs. novel words) were correlated with fMRI signal change during processing of novel versus familiar words using a covariance model implemented in SPM96. For the novel words analysis, voxels in the right anterior hippocampus correlated significantly with Trial 1 (r = .76 at the maxima). For the recognition analysis, a significant cluster of voxels was found in the right dorsolateral prefrontal cortex (r = .88 at the maxima). Our prior results of separable left medial temporal activation to novel and familiar words, together with results of the covariance analyses reported here, suggest that in addition to the left medial temporal lobe (MTL) regions that are engaged during novel and familiar word processing, the right hippocampus and right frontal lobe are also involved, particularly in those participants with better memory ability. This positive relationship between fMRI activation and CVLT performance suggests a role for these right hemisphere regions in successful memory processing of verbal material, perhaps reflecting more efficient encoding and retrieval strategies that facilitate memory. (JINS, 2001, 7, 55–62.)

scholarly journals Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning

2021 ◽  
Vol 5 ◽  
pp. 239821282110027
Author(s):  
Markus Bauer ◽  
Matthew G. Buckley ◽  
Tobias Bast
Keyword(s):  
Individual Differences ◽  
Spatial Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Place Learning ◽  
Theta Band ◽  
Delayed Matching ◽  
Place Task ◽  
The Right ◽  
Encoding And Retrieval

Spatial memory has been closely related to the medial temporal lobe and theta oscillations are thought to play a key role. However, it remains difficult to investigate medial temporal lobe activation related to spatial memory with non-invasive electrophysiological methods in humans. Here, we combined the virtual delayed-matching-to-place task, reverse-translated from the watermaze delayed-matching-to-place task in rats, with high-density electroencephalography recordings. Healthy young volunteers performed this computerised task in a virtual circular arena, which contained a hidden target whose location moved to a new place every four trials, allowing the assessment of rapid memory formation. Using behavioural measures as predictor variables for source reconstructed frequency-specific electroencephalography power, we found that inter-individual differences in ‘search preference’ during ‘probe trials’, a measure of one-trial place learning known from rodent studies to be particularly hippocampus-dependent, correlated predominantly with distinct theta-band oscillations (approximately 7 Hz), particularly in the right temporal lobe, the right striatum and inferior occipital cortex or cerebellum. This pattern was found during both encoding and retrieval/expression, but not in control analyses and could not be explained by motor confounds. Alpha-activity in sensorimotor and parietal cortex contralateral to the hand used for navigation also correlated (inversely) with search preference. This latter finding likely reflects movement-related factors associated with task performance, as well as a frequency difference in (ongoing) alpha-rhythm for high-performers versus low-performers that may contribute to these results indirectly. Relating inter-individual differences in ongoing brain activity to behaviour in a continuous rapid place-learning task that is suitable for a variety of populations, we could demonstrate that memory-related theta-band activity in temporal lobe can be measured with electroencephalography recordings. This approach holds great potential for further studies investigating the interactions within this network during encoding and retrieval, as well as neuromodulatory impacts and age-related changes.

Cognitive impairment and medial temporal lobe structure in young adults with a depressive episode

2018 ◽  
Vol 237 ◽  
pp. 112-117 ◽  
Author(s):  
Markus Donix ◽  
Robert Haussmann ◽  
Franziska Helling ◽  
Anne Zweiniger ◽  
Jan Lange ◽  
...  
Keyword(s):  
Young Adults ◽  
Cognitive Impairment ◽  
Temporal Lobe ◽  
Depressive Episode ◽  
Medial Temporal Lobe

The ratio of posterior–anterior medial temporal lobe volumes predicts source memory performance in healthy young adults

Hippocampus ◽  
2020 ◽  
Vol 30 (11) ◽  
pp. 1209-1227
Author(s):  
Jamie Snytte ◽  
Abdelhalim Elshiekh ◽  
Sivaniya Subramaniapillai ◽  
Lyssa Manning ◽  
Stamatoula Pasvanis ◽  
...  
Keyword(s):  
Young Adults ◽  
Temporal Lobe ◽  
Source Memory ◽  
Medial Temporal Lobe ◽  
Memory Performance ◽  
Posterior Anterior

scholarly journals Intrinsic medial temporal lobe connectivity relates to individual differences in episodic autobiographical remembering

Cortex ◽  
2016 ◽  
Vol 74 ◽  
pp. 206-216 ◽  
Author(s):  
Signy Sheldon ◽  
Norman Farb ◽  
Daniela J. Palombo ◽  
Brian Levine
Keyword(s):  
Individual Differences ◽  
Temporal Lobe ◽  
Medial Temporal Lobe
Sign in / Sign up

Export Citation Format

Share Document