scholarly journals Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation

2009 ◽  
Vol 106 (31) ◽  
pp. 12861-12866 ◽  
Author(s):  
D. G. T. Su ◽  
H. Fang ◽  
M. L. Gross ◽  
J.-S. A. Taylor
1999 ◽  
Vol 274 (35) ◽  
pp. 24779-24786 ◽  
Author(s):  
Ryujiro Hara ◽  
Christopher P. Selby ◽  
Mingyi Liu ◽  
David H. Price ◽  
Aziz Sancar

2014 ◽  
Vol 136 (42) ◽  
pp. 14801-14810 ◽  
Author(s):  
Hideo Ando ◽  
Benjamin P. Fingerhut ◽  
Konstantin E. Dorfman ◽  
Jason D. Biggs ◽  
Shaul Mukamel

2015 ◽  
Vol 18 (4) ◽  
pp. 600 ◽  
Author(s):  
Sabia Maini ◽  
Brian M. Fahlman ◽  
Ed S. Krol

Purpose: Exposure of skin to ultraviolet light has been shown to have a number of deleterious effects including photoaging, photoimmunosuppression and photoinduced DNA damage which can lead to the development of skin cancer.  In this paper we present a study on the ability of three flavonols to protect EpiDerm™, an artificial skin mimic, against UV-induced damage. Methods: EpiDerm™ samples were treated with flavonol in acetone and exposed to UVA (100 kJ/m2 at 365 nm) and UVB (9000 J/m2 at 310 nm) radiation.  Secretion of matrix metalloproteinase-1 (MMP-1) and tumor necrosis factor-α (TNF-a) were determined by ELISA, cyclobutane pyrimidine dimers were quantified using LC-APCI-MS. Results: EpiDerm ™ treated topically with quercetin significantly decreased MMP-1 secretion induced by UVA (100 µM) or UVB (200 µM) and TNF-a secretion was significantly reduced at 100 µM quercetin for both UVA and UVB radiation.  In addition, topically applied quercetin was found to be photostable over the duration of the experiment.  EpiDerm™ samples were treated topically with quercetin, kaempferol or galangin (52 µM) immediately prior to UVA or UVB exposure, and the cyclobutane thymine dimers (T-T (CPD)) were quantified using an HPLC-APCI MS/MS method.  All three flavonols significantly decreased T-T (CPD) formation in UVB irradiated EpiDerm™, however no effect could be observed for the UVA irradiation experiments as thymine dimer formation was below the limit of quantitation.  Conclusions: Our results suggest that flavonols can provide protection against UV radiation-induced skin damage through both antioxidant activity and direct photo-absorption. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.


2016 ◽  
Vol 7 (21) ◽  
pp. 4391-4397 ◽  
Author(s):  
Jesús I. Mendieta-Moreno ◽  
Daniel G. Trabada ◽  
Jesús Mendieta ◽  
James P. Lewis ◽  
Paulino Gómez-Puertas ◽  
...  

Biochemistry ◽  
1993 ◽  
Vol 32 (28) ◽  
pp. 7065-7068 ◽  
Author(s):  
Sang Tae Kim ◽  
Khushbeer Malhotra ◽  
Colin A. Smith ◽  
John Stephen Taylor ◽  
Aziz Sancar

RSC Advances ◽  
2017 ◽  
Vol 7 (87) ◽  
pp. 55098-55105 ◽  
Author(s):  
Yating Gao ◽  
Tianlei Guang ◽  
Xiaodong Ye

Analytical ultracentrifugation sedimentation velocity (AUC-SV) was used to study the interactions between TMPyP4 and AGGG(TTAGGG)3 (Tel22) and the TMPyP4-induced dimer formation of G-quadruplex.


2011 ◽  
Vol 108 (23) ◽  
pp. 9402-9407 ◽  
Author(s):  
V. Thiagarajan ◽  
M. Byrdin ◽  
A. P. M. Eker ◽  
P. Muller ◽  
K. Brettel

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