B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1

The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor–triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.

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Formation of Virus-like Clusters Is an Intrinsic Property of the Tumor Necrosis Factor Family Member BAFF (B Cell Activating Factor)†

Biochemistry ◽

10.1021/bi051685o ◽

2006 ◽

Vol 45 (7) ◽

pp. 2006-2013 ◽

Cited By ~ 45

Author(s):

Teresa G. Cachero ◽

Ian M. Schwartz ◽

Fang Qian ◽

Eric S. Day ◽

Claudia Bossen ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

B Cell ◽

Family Member ◽

Tumor Necrosis ◽

Intrinsic Property ◽

Tumor Necrosis Factor Family ◽

B Cell Activating Factor ◽

Necrosis Factor

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Faculty Opinions recommendation of The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10573958.789552852 ◽

2012 ◽

Author(s):

James Martin

Keyword(s):

Tumor Necrosis Factor ◽

Family Member ◽

Tumor Necrosis ◽

Airway Remodeling ◽

Asthmatic Airway ◽

Tumor Necrosis Factor Family ◽

Necrosis Factor

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TACI and BAFF-R mediate isotype switching in B cells

Journal of Experimental Medicine ◽

10.1084/jem.20032000 ◽

2005 ◽

Vol 201 (1) ◽

pp. 35-39 ◽

Cited By ~ 364

Author(s):

Emanuela Castigli ◽

Stephen A. Wilson ◽

Sumi Scott ◽

Fatma Dedeoglu ◽

Shengli Xu ◽

...

Keyword(s):

B Cells ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Cell Maturation ◽

Isotype Switching ◽

B Cell Maturation ◽

Human B Cells ◽

Necrosis Factor ◽

B Cell Maturation Antigen

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.

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