scholarly journals Somatic cell hybrids between mouse peritoneal macrophages and simian-virus-40-transformed human cells: II. Presence of human chromosome 7 carrying simin virus 40 genome in cells of tumors induced by hybrid cells.

1975 ◽  
Vol 72 (4) ◽  
pp. 1397-1400 ◽  
Author(s):  
C. M. Croce ◽  
D. Aden ◽  
H. Koprowski
Keyword(s):  
Human Chromosome ◽  
Somatic Cell ◽  
Simian Virus 40 ◽  
Peritoneal Macrophages ◽  
Simian Virus ◽  
Chromosome 7 ◽  
Hybrid Cells ◽  
Somatic Cell Hybrids ◽  
Mouse Peritoneal Macrophages ◽  
Human Chromosome 7

scholarly journals CONCORDANT SEGREGATION OF THE EXPRESSION OF SV40 T ANTIGEN AND HUMAN CHROMOSOME 7 IN MOUSE-HUMAN HYBRID SUBCLONES

1974 ◽  
Vol 139 (5) ◽  
pp. 1350-1353 ◽  
Author(s):  
Carlo M. Croce ◽  
Hilary Koprowski
Keyword(s):  
Human Chromosome ◽  
Thymidine Kinase ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
T Antigen ◽  
Chromosome 7 ◽  
Sv40 T Antigen ◽  
Mouse Cells ◽  
Sv40 Genome ◽  
Human Chromosome 7

Subcloning of Simian virus 40 (SV40) T antigen-positive mouse-human hybrids, derived from the fusion of mouse cells deficient in thymidine kinase with SV40-transformed Lesch Nyhan fibroblasts, resulted in their segregation into T antigen-positive and negative subclones. Positive correlation between the presence of human chromosome 7 and the expression of SV40 T antigen was established in the subclones examined. These results negate the possibility of a transfer of the SV40 genome to a mouse chromosome.

scholarly journals Complement-mediated antiserum cytotoxic reactions to human chromosome 7 coded antigen(s): immunoselection of rearranged human chromosome 7 in human-mouse somatic cell hybrids.

1977 ◽  
Vol 145 (2) ◽  
pp. 314-326 ◽  
Author(s):  
B B Knowles ◽  
D Solter ◽  
G Trinchieri ◽  
K M Maloney ◽  
S R Ford ◽  
...  
Keyword(s):  
Cell Surface ◽  
Human Chromosome ◽  
Somatic Cell ◽  
Surface Antigen ◽  
Chromosome 7 ◽  
Cell Surface Antigen ◽  
Somatic Cell Hybrids ◽  
Cell Hybrids ◽  
Human Chromosome 7 ◽  
Mouse Somatic Cell

Immunoselection via complement-dependent lysis of human-mouse somatic cell hybrids containing chromosome 7, with antisera reactive to cell surface antigen(s) coded for by chromosome 7, has resulted in growth of somatic cell hybrids containing rearranged human chromosome 7s. Investigation of these hybrids has localized the gene(s) coding for the relevant cell surface antigen(s) to the short arm of human chromosome 7. The simian virus 40 integration site and the gene coding for human beta-glucuronidase appear to be localized to the long arm of chromosome 7 in this hybrid clone.

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