scholarly journals Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.

1983 ◽  
Vol 80 (23) ◽  
pp. 7155-7159 ◽  
Author(s):  
G. L. Smith ◽  
B. R. Murphy ◽  
B. Moss
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Vaccinia Virus ◽  
Influenza Virus Infection ◽  
Influenza Hemagglutinin ◽  
Hemagglutinin Gene ◽  
Virus Recombinant ◽  
Vaccinia Virus Recombinant

scholarly journals Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus Infection

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e57894 ◽  
Author(s):  
Olivier Leymarie ◽  
Grégory Jouvion ◽  
Pierre-Louis Hervé ◽  
Christophe Chevalier ◽  
Valérie Lorin ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Kinetic Characterization ◽  
H5n1 Influenza Virus ◽  
Highly Pathogenic ◽  
H5n1 Influenza ◽  
Avian H5n1 Influenza Virus

Influenza hemagglutinin vaccine with poly(γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity

Vaccine ◽  
2007 ◽  
Vol 25 (49) ◽  
pp. 8270-8278 ◽  
Author(s):  
Shigefumi Okamoto ◽  
Hironori Yoshii ◽  
Takami Akagi ◽  
Mitsuru Akashi ◽  
Toyokazu Ishikawa ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Glutamic Acid ◽  
Influenza Virus Infection ◽  
Cell Mediated Immunity ◽  
Influenza Hemagglutinin

scholarly journals Characterization of a new H-2Dk-restricted epitope prominent in primary influenza A virus infection

2001 ◽  
Vol 82 (7) ◽  
pp. 1749-1755 ◽  
Author(s):  
Sophie Tourdot ◽  
Shan Herath ◽  
Keith G. Gould
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Dominance Hierarchy ◽  
Influenza Virus Infection ◽  
Amino Acid Residues ◽  
Influenza A Virus Infection ◽  
Restricted Epitope

Influenza A virus infection of mice has been used extensively as a model to investigate the mechanisms of antigen presentation to cytotoxic T lymphocytes (CTL) and the phenomenon of immunodominance in antiviral CTL responses. The different virus-encoded epitopes that are recognized in H-2b and H-2d mice have been characterized and their relative immunodominance has been well-studied. In H-2k mice, four different Kk-restricted influenza virus epitopes have been described, but the dominance hierarchy of these epitopes is unknown and there is also an uncharacterized Dk-restricted response against the virus. In this study, a Dk-restricted epitope derived from the influenza virus A/PR/8/34 polymerase protein PB1, corresponding to amino acid residues 349–357 (ARLGKGYMF), was identified. This peptide is the major epitope within the PB1 polymerase and is at least as dominant as any of the four Kk-restricted epitopes that are recognized in CBA mice following primary influenza virus infection. The PB1 epitope is only the fourth Dk-presented peptide to be reported and the sequence of this epitope confirms a Dk-restricted peptide motif, consisting of arginine at position two, arginine or lysine at position five and a hydrophobic residue at the carboxy terminus.

scholarly journals Phenotypic and functional characteristics of a novel influenza hemagglutinin-specific memory NK cell

2021 ◽  
Author(s):  
Jian Zheng ◽  
Liyan Wen ◽  
Hui-Ling Yen ◽  
Ming Liu ◽  
Yinping Liu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Nk Cells ◽  
Nk Cell ◽  
Cell Subset ◽  
Influenza Virus Infection ◽  
Immune Memory ◽  
Influenza Hemagglutinin ◽  
Ifn Γ ◽  
Memory Nk Cells

Immune memory represents the most efficient defense against invasion and transmission of infectious pathogens. In contrast to memory T and B cells, the roles of innate immunity in recall responses remain inconclusive. In this study, we identified a novel mouse spleen NK cell subset expressing NKp46 and NKG2A induced by intranasal influenza virus infection. These memory NK cells specifically recognize N-linked glycosylation sites on influenza hemagglutinin (HA) protein. Different from memory-like NK cells reported previously, these NKp46+NKG2A+ memory NK cells exhibited HA-specific silence of cytotoxicity but increase of IFN-γ response against influenza virus-infected cells, which could be reversed by Pifithrin-μ, a p53-HSP70 signaling inhibitor. During recall responses, splenic NKp46+NKG2A+ NK cells were recruited to infected lung and modulated viral clearance of virus and CD8+ T cell distribution, resulting in improved clinical outcomes. This long-lived NK memory bridges innate and adaptive immune memory response and promotes the homeostasis of local environment during recall response. Importance In this study, we demonstrate a novel HA-specific NKp46+NKG2A+ NK cell subset induced by influenza A virus infection. These memory NK cells show virus-specific decreased cytotoxicity and increased IFN-γ on re-encountering the same influenza virus antigen. In addition, they modulate host recall responses and CD8 T cell distribution, thus bridging the innate immune and adaptive immune responses during influenza virus infection.

Characterization of porcine P58IPK gene and its up-regulation after H1N1 or H3N2 influenza virus infection

2013 ◽  
Vol 58 (1) ◽  
pp. 120-126 ◽  
Author(s):  
Pengfei Jiang ◽  
Junge Wen ◽  
Hao Song ◽  
Xinyu Chen ◽  
Yan Sun ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
H3n2 Influenza ◽  
H3n2 Influenza Virus
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