scholarly journals Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets.

1983 ◽  
Vol 80 (23) ◽  
pp. 7224-7228 ◽  
Author(s):  
A. Kupfer ◽  
G. Dennert ◽  
S. J. Singer
Keyword(s):  
Natural Killer Cells ◽  
Golgi Apparatus ◽  
Natural Killer ◽  
Microtubule Organizing Center ◽  
Killer Cells ◽  
Organizing Center

scholarly journals Rapid Lytic Granule Convergence to the MTOC in Natural Killer Cells Is Dependent on Dynein But Not Cytolytic Commitment

2010 ◽  
Vol 21 (13) ◽  
pp. 2241-2256 ◽  
Author(s):  
Ashley N. Mentlik ◽  
Keri B. Sanborn ◽  
Erika L. Holzbaur ◽  
Jordan S. Orange
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Immunological Synapse ◽  
Microtubule Organizing Center ◽  
Directed Movement ◽  
Killer Cells ◽  
Lytic Granules ◽  
Dynein Motor ◽  
Mediate Cytotoxicity ◽  
Time Required

Natural killer cells are lymphocytes specialized to participate in host defense through their innate ability to mediate cytotoxicity by secreting the contents of preformed secretory lysosomes (lytic granules) directly onto a target cell. This form of directed secretion requires the formation of an immunological synapse and occurs stepwise with actin reorganization preceding microtubule-organizing center (MTOC) polarization to the synapse. Because MTOC polarization to the synapse is required for polarization of lytic granules, we attempted to define their interrelationship. We found that compared with the time required for MTOC polarization, lytic granules converged to the MTOC rapidly. The MTOC-directed movement of lytic granules was independent of actin and microtubule reorganization, dependent on dynein motor function, occurred before MTOC polarization, and did not require a commitment to cytotoxicity. This defines a novel paradigm for rapid MTOC-directed transport as a prerequisite for directed secretion, one that may prepare, but not commit cells for precision secretory function.

Natural Killer cells exhibit direct activity against medical important fungi

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
S Schmidt ◽  
L Tramsen ◽  
M Hanisch ◽  
S Huenecke ◽  
U Koehl ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells
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