scholarly journals Neural cell adhesion molecule (N-CAM) inhibits astrocyte proliferation after injury to different regions of the adult rat brain.

1995 ◽  
Vol 92 (10) ◽  
pp. 4323-4327 ◽  
Author(s):  
L. A. Krushel ◽  
O. Sporns ◽  
B. A. Cunningham ◽  
K. L. Crossin ◽  
G. M. Edelman
Keyword(s):  
Cell Adhesion ◽  
Rat Brain ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Astrocyte Proliferation ◽  
Adult Rat ◽  
Neural Cell Adhesion ◽  
Adult Rat Brain

Localization of neural cell adhesion molecule (N-CAM) immunoreactivity in adult rat tissues

2002 ◽  
Vol 77 (3) ◽  
pp. 127-135 ◽  
Author(s):  
S Filiz ◽  
H Dalcik ◽  
M Yardimoglu ◽  
S Gonca ◽  
S Ceylan
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Rat Tissues ◽  
Adult Rat ◽  
Neural Cell Adhesion

scholarly journals Transcription initiation sites and structural organization of the extreme 5' region of the rat neural cell adhesion molecule gene.

1990 ◽  
Vol 10 (7) ◽  
pp. 3314-3324 ◽  
Author(s):  
A S Chen ◽  
A Reyes ◽  
R Akeson
Keyword(s):  
Cell Adhesion ◽  
Rat Brain ◽  
Adhesion Molecule ◽  
Transcription Initiation ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Regulatory Elements ◽  
Neural Cell ◽  
Essential Information ◽  
Neural Cell Adhesion

Through analysis of rat genomic cosmid clones, the 5'-most exon of the rat neural cell adhesion molecule (NCAM) gene was identified. This exon, here named exon 0, contained the entire 5' untranslated region and the N-terminal signal sequence of the polypeptide. Exon 0 was isolated from a 1.6-kilobase (kb) EcoRI-HindIII fragment of rat genomic cosmid clone 9 which was 35 kb in length. This fragment was sequenced and found to contain approximately 940 base pairs (bp) of 5'-flanking sequence, exon 0, which was approximately 245 bp in length, and approximately 400 bp of the following intron 0. By using information derived from this fragment and the pR18 rat NCAM cDNA, the transcription initiation sites were determined with two assays. Both primer extensions and nuclease S1 protection assays of postnatal day 7 rat brain RNA identified seven initiation sites within a single 10-bp region at positions -195 to -186 relative to the translation start site. An additional minor site was found at position -329. In the immediate 5' region, no consensus TATA or CCAAT sequences were found. Potential regulatory elements within this region include Sp1 consensus binding sites and also a 178-bp homopurine-homopyrimidine sequence containing several mirror repeats. NCAM has multiple transcripts which are regulated in a developmental and tissue-specific fashion. To determine whether these transcripts are initiated at the same sites, transcription initiation sites were analyzed in postnatal day 7 and adult rat brain and also in cultured cell lines of neuronal, glial, and muscle phenotypes. These tissues and cells exhibited distinct NCAM transcript populations in Northern (RNA) dot blot analysis. In all cases similar transcription start sites were found, suggesting that all major NCAM transcripts have similar or identical initiation sites. These results provide essential information to begin analysis of NCAM regulation in different tissues and during development.

Characterization of Soluble Neural Cell Adhesion Molecule in Rat Brain, CSF, and Plasma

1992 ◽  
Vol 59 (3) ◽  
pp. 838-847 ◽  
Author(s):  
Lisbeth Krog ◽  
Marianne Olsen ◽  
Anne-Marie Dalseg ◽  
Jürgen Roth ◽  
Elisabeth Bock
Keyword(s):  
Cell Adhesion ◽  
Rat Brain ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Neural Cell Adhesion
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