scholarly journals An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele.

1996 ◽  
Vol 93 (10) ◽  
pp. 5094-5098 ◽  
Author(s):  
D. G. Forcione ◽  
B. Sands ◽  
K. J. Isselbacher ◽  
A. Rustgi ◽  
D. K. Podolsky ◽  
...  
Gut ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 395-401 ◽  
Author(s):  
P C F Stokkers ◽  
P H Reitsma ◽  
G N J Tytgat ◽  
S J H van Deventer

BACKGROUNDSusceptibility to inflammatory bowel disease (IBD) is partially genetically determined and the HLA class II genes are candidates for a role in genetic susceptibility to IBD, because their products play a central role in the immune response. Multiple studies have reported associations between HLA-DR or -DQ phenotypes and either ulcerative colitis or Crohn’s disease, but much of the data are still controversial.AIMSTo estimate overall associations between HLA class II phenotypes and IBD, and to establish the relative risk conferred by HLA-DR and -DQ phenotypes by meta-analysis.METHODSMedline was searched for publications reporting on the relation between IBD and HLA class II phenotypes. Raw data were extracted by recalculating the number of phenotypes or the number of alleles of the main antigens. Odds ratios and confidence intervals were calculated according to the Mantel-Haenszel method.RESULTSDR2, DR9, and DRB1*0103 were positively associated with ulcerative colitis, and a negative association was found for DR4 and ulcerative colitis. For Crohn’s disease a positive association was found with DR7, DRB3*0301, and DQ4 and a negative association with DR2 and DR3.CONCLUSIONSBoth ulcerative colitis and Crohn’s disease are associated with specific HLA class II phenotypes. Further analysis of these phenotypes and subgroup analysis may elucidate how these alleles contribute to susceptibility to IBD.


1998 ◽  
Vol 114 ◽  
pp. A989
Author(s):  
B. Gulwani-Akolkar ◽  
P.N. Akolkar ◽  
X.Y. Lin ◽  
R. Manji ◽  
S. Katz ◽  
...  

Gut ◽  
1996 ◽  
Vol 38 (4) ◽  
pp. 538-542 ◽  
Author(s):  
M Reinshagen ◽  
C Loeliger ◽  
P Kuehnl ◽  
U Weiss ◽  
B J Manfras ◽  
...  

2007 ◽  
Vol 6 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Beena Gulwani-Akolkar ◽  
Pradip N. Akolkar ◽  
Xing-Yu Lin ◽  
Denis Heresbach ◽  
Ryhana Manji ◽  
...  

Gut ◽  
1996 ◽  
Vol 39 (1) ◽  
pp. 69-72 ◽  
Author(s):  
P M Danze ◽  
J F Colombel ◽  
S Jacquot ◽  
M N Loste ◽  
D Heresbach ◽  
...  

2003 ◽  
Vol 17 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Hugh J Freeman

Earlier investigations demonstrate an increased risk for colon cancer in Crohn's disease. For other intestinal neoplasms, such as carcinoids, studies are limited. In Crohn's disease, repeated endoscopic and imaging studies along with intestinal resections may facilitate clinical recognition of neoplastic diseases, including appendiceal neoplasms. To date, however, only sporadic cases of appendiceal carcinoids have been described in Crohn's disease. In the present study, in a single clinician database of 1000 Crohn's disease patients, three of the 441 patients who had undergone intestinal resection had appendiceal carcinoids, all of which were pathologically confirmed. All were observed in female patients and were not suspected before surgical treatment. In one case, even though management was not altered, the tumour had already invaded serosal fat indicating a potential for more advanced disease. In this series, a carcinoid tumour was found in a resection specimen during a later clinical case review and another was a microcarcinoid, implying that these tumours may be overlooked in Crohn's disease. The percentage detected in the entire database (0.3%) exceeds the reported rates of detection of appendiceal carcinoids after removal of the appendix for appendicitis, as well as the rate of detection of appendiceal carcinoids in autopsy studies. This percentage would be higher if only those having an intestinal resection were considered (0.68%). Additional studies are needed to further define this risk of appendiceal carcinoids in Crohn's disease.


2021 ◽  
Vol 160 (6) ◽  
pp. S-80
Author(s):  
Simon Chan ◽  
Ye Chen ◽  
Kevin Casey ◽  
Ola Olen ◽  
Jonas F. Ludvigsson ◽  
...  

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