scholarly journals The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation

1997 ◽  
Vol 94 (6) ◽  
pp. 2249-2254 ◽  
Author(s):  
N. Ali ◽  
A. Siddiqui
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Noncoding Region ◽  
Hepatitis C Virus Rna ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Virus Rna ◽  
La Antigen

scholarly journals Internal ribosome entry site within hepatitis C virus RNA.

1992 ◽  
Vol 66 (3) ◽  
pp. 1476-1483 ◽  
Author(s):  
K Tsukiyama-Kohara ◽  
N Iizuka ◽  
M Kohara ◽  
A Nomoto
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Hepatitis C Virus Rna ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Virus Rna

scholarly journals Human La Antigen Is Required for the Hepatitis C Virus Internal Ribosome Entry Site-mediated Translation

2000 ◽  
Vol 275 (36) ◽  
pp. 27531-27540 ◽  
Author(s):  
Naushad Ali ◽  
Ger J.M. Pruijn ◽  
Daniel J. Kenan ◽  
Jack D. Keene ◽  
Aleem Siddiqui
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
La Antigen ◽  
Virus Internal Ribosome Entry

scholarly journals A Modular Approach to Synthetic RNA Binders of the Hepatitis C Virus Internal Ribosome Entry Site

ChemBioChem ◽  
2010 ◽  
Vol 11 (10) ◽  
pp. 1364-1367 ◽  
Author(s):  
Maia Carnevali ◽  
Jerod Parsons ◽  
David L. Wyles ◽  
Thomas Hermann
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Modular Approach ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Rna Binders ◽  
Virus Internal Ribosome Entry

scholarly journals Differential Effects on the Hepatitis C Virus (HCV) Internal Ribosome Entry Site by Vitamin B12 and the HCV Core Protein

2004 ◽  
Vol 78 (21) ◽  
pp. 12075-12081 ◽  
Author(s):  
Dongsheng Li ◽  
William B. Lott ◽  
John Martyn ◽  
Gholamreza Haqshenas ◽  
Eric J. Gowans
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Core Protein ◽  
Vitamin B ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Hcv Core Protein ◽  
Hcv Ires

ABSTRACT To investigate the role of the hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain the reciprocal domain IV in the otherwise HCV and classical swine fever virus IRES elements. This permitted an examination of the role of domain IV in the control of HCV translation. A specific inhibitor of the HCV IRES, vitamin B12, was shown to inhibit translation directed by all IRES elements which contained domain IV from the HCV and the GB virus B IRES elements, whereas the HCV core protein could only suppress translation from the wild-type HCV IRES. Thus, the mechanisms of translation inhibition by vitamin B12 and the core protein differ, and they target different regions of the IRES.

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