scholarly journals cea5, a Structurally Divergent Member of the Murine Carcinoembryonic Antigen Gene Family, Is Exclusively Expressed during Early Placental Development in Trophoblast Giant Cells

1997 ◽  
Vol 272 (50) ◽  
pp. 31369-31376 ◽  
Author(s):  
Daniela Finkenzeller ◽  
Beril Kromer ◽  
John Thompson ◽  
Wolfgang Zimmermann
Keyword(s):  
Gene Family ◽  
Carcinoembryonic Antigen ◽  
Giant Cells ◽  
Placental Development ◽  
Antigen Gene ◽  
Trophoblast Giant Cells

scholarly journals Molecular cloning of a gene belonging to the carcinoembryonic antigen gene family and discussion of a domain model.

1987 ◽  
Vol 84 (9) ◽  
pp. 2965-2969 ◽  
Author(s):  
J. A. Thompson ◽  
H. Pande ◽  
R. J. Paxton ◽  
L. Shively ◽  
A. Padma ◽  
...  
Keyword(s):  
Gene Family ◽  
Carcinoembryonic Antigen ◽  
Molecular Cloning ◽  
Domain Model ◽  
Antigen Gene

scholarly journals Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

1991 ◽  
Vol 5 (5) ◽  
pp. 344-366 ◽  
Author(s):  
John A. Thompson ◽  
Fritz Grunert ◽  
Wolfgang Zimmermann
Keyword(s):  
Molecular Biology ◽  
Gene Family ◽  
Carcinoembryonic Antigen ◽  
Antigen Gene

High expression of CEACAM19, a new member of carcinoembryonic antigen gene family, in patients with breast cancer

2016 ◽  
Vol 17 (4) ◽  
pp. 547-553 ◽  
Author(s):  
Mehrdad Asghari Estiar ◽  
Rezvan Esmaeili ◽  
Ali-Akbar Zare ◽  
Leila Farahmand ◽  
Hassan Fazilaty ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Family ◽  
Carcinoembryonic Antigen ◽  
High Expression ◽  
Antigen Gene

The structure, metabolism and function of the carcinoembryonic antigen gene family

1990 ◽  
Vol 1032 (2-3) ◽  
pp. 177-189 ◽  
Author(s):  
Peter Thomas ◽  
Carol Ann Toth ◽  
Kulvinder S. Saini ◽  
J. Milburn Jessup ◽  
Glenn Steele
Keyword(s):  
Gene Family ◽  
Carcinoembryonic Antigen ◽  
Antigen Gene ◽  
And Function

scholarly journals Characterization of murine carcinoembryonic antigen gene family members

1992 ◽  
Vol 3 (5) ◽  
pp. 262-273 ◽  
Author(s):  
Fritz Rudert ◽  
Ann M. Saunders ◽  
Sabine Rebstock ◽  
John A. Thompson ◽  
Wolfgang Zimmermann
Keyword(s):  
Gene Family ◽  
Carcinoembryonic Antigen ◽  
Family Members ◽  
Antigen Gene

scholarly journals Identification of a Carcinoembryonic Antigen Gene Family in The Rat

1989 ◽  
Vol 264 (12) ◽  
pp. 6906-6912 ◽  
Author(s):  
V Kodelja ◽  
K Lucas ◽  
S Barnert ◽  
S von Kleist ◽  
J A Thompson ◽  
...  
Keyword(s):  
Gene Family ◽  
Carcinoembryonic Antigen ◽  
Antigen Gene

scholarly journals Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xiwen Hu ◽  
Jiangchao Li ◽  
Qianqian Zhang ◽  
Lingyun Zheng ◽  
Guang Wang ◽  
...  
Keyword(s):  
Fetal Death ◽  
Underlying Mechanism ◽  
Giant Cells ◽  
Placental Development ◽  
Genetic Inactivation ◽  
Chorioallantoic Placenta ◽  
Phosphoinositide 3 Kinase ◽  
Trophoblast Giant Cells ◽  
Mammalian Embryonic Development

Abstract Maternal PI3K p110δ has been implicated in smaller litter sizes in mice, but its underlying mechanism remains unclear. The placenta is an indispensable chimeric organ that supports mammalian embryonic development. Using a mouse model of genetic inactivation of PI3K p110δ (p110δD910A/D910A), we show that fetuses carried by p110δD910A/D910A females were growth retarded and showed increased mortality in utero mainly during placentation. The placentas in p110δD910A/D910A females were anomalously anemic, exhibited thinner spongiotrophoblast layer and looser labyrinth zone, which indicate defective placental vasculogenesis. In addition, p110δ was detected in primary trophoblast giant cells (P-TGC) at early placentation. Maternal PI3K p110δ inactivation affected normal TGCs generation and expansion, impeded the branching of chorioallantoic placenta but enhanced the expression of matrix metalloproteinases (MMP-2, MMP-12). Poor vasculature support for the developing fetoplacental unit resulted in fetal death or gross growth retardation. These data, taken together, provide the first in vivo evidence that p110δ may play an important role in placental vascularization through manipulating trophoblast giant cell.

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