Loss-of-function and Dominant-negative Mechanisms Associated with Hepatocyte Nuclear Factor-1β Mutations in Familial Type 2 Diabetes Mellitus

Journal of Biological Chemistry ◽

10.1074/jbc.274.19.12975 ◽

1999 ◽

Vol 274 (19) ◽

pp. 12975-12978 ◽

Author(s):

Hideaki Tomura ◽

Hidekazu Nishigori ◽

Kimie Sho ◽

Kazuya Yamagata ◽

Ituro Inoue ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Dominant Negative ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

Loss Of Function ◽

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Studies of the variability of the hepatocyte nuclear factor-1β (HNF-1β / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and β-cell function

Human Mutation ◽

10.1002/humu.1201 ◽

2001 ◽

Vol 18 (4) ◽

pp. 356-357 ◽

Author(s):

Jakob Ek ◽

Niels Grarup ◽

Søren A. Urhammer ◽

Peter H. Gaede ◽

Thomas Drivsholm ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cell Function ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

Β Cell ◽

Β Cell Function

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Identification of a new mutation in the hepatocyte nuclear factor-1 α gene in a polish family with early onset type 2 diabetes mellitus

Diabetes Research and Clinical Practice ◽

10.1016/s0168-8227(00)81784-2 ◽

2000 ◽

Vol 50 ◽

pp. 96

Author(s):

Maciej T. Malecki ◽

Tomasz Klupa ◽

Jakub Frey ◽

Katarzyna Cyganek ◽

Danuta Galicka-Stankowska ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Early Onset ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

New Mutation ◽

Nuclear Factor 1

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Mutations in the hepatocyte nuclear factor-1α gene (MODY3) are not a major cause of early-onset non-insulin-dependent (type 2) diabetes mellitus in Japanese

Journal of Human Genetics ◽

10.1007/s100380050049 ◽

1998 ◽

Vol 43 (2) ◽

pp. 107-110 ◽

Author(s):

Hidekazu Nishigori ◽

Shirou Yamada ◽

Tomoko Kohama ◽

Toshihiro Utsugi ◽

Hiroyuki Shimizu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Early Onset ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

Insulin Dependent ◽

Hepatocyte Nuclear Factor 1Α ◽

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Identification of new mutations in the hepatocyte nuclear factor 4a gene among families with early onset Type 2 diabetes mellitus

Diabetic Medicine ◽

10.1046/j.1464-5491.1999.00073.x ◽

1999 ◽

Vol 16 (3) ◽

pp. 193-200 ◽

Author(s):

M. T. Malecki ◽

Y. Yang ◽

A. Antonellis ◽

S. Curtis ◽

J. H. Warram ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Early Onset ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

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A novel mutation in the hepatocyte nuclear factor-1alpha/MODY3 gene in Chinese subjects with early-onset Type 2 diabetes mellitus in Taiwan

Diabetic Medicine ◽

10.1046/j.1464-5491.2000.00285.x ◽

2000 ◽

Vol 17 (5) ◽

pp. 390-393 ◽

Author(s):

T. -S. Jap ◽

Y. -C. Wu ◽

J. Y. Chiou ◽

C. -F. Kwok

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Early Onset ◽

Novel Mutation ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

Chinese Subjects

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I27L Polymorphism in hepatocyte nuclear factor-1α gene and type 2 diabetes mellitus: A meta-analysis of studies about orient population (Chinese and Japanese)

International Journal of Diabetes Mellitus ◽

10.1016/j.ijdm.2009.12.011 ◽

2010 ◽

Vol 2 (1) ◽

pp. 28-31 ◽

Author(s):

Tao Chen ◽

Xu Cao ◽

Yang Long ◽

Xiangxun Zhang ◽

Honglin Yu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Meta Analysis ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

Hepatocyte Nuclear Factor 1Α

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Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset Type 2 diabetes mellitus/MODY

Diabetic Medicine ◽

10.1046/j.1464-5491.1999.00188.x ◽

1999 ◽

Vol 16 (11) ◽

pp. 956-963 ◽

Author(s):

M. C. Y. Ng ◽

B. N. Cockburn ◽

T. H. Lindner ◽

V. T. F. Yeung ◽

C. -C. Chow ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Molecular Genetics ◽

Early Onset ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

Genetics Of Diabetes ◽

Chinese Subjects

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Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation

Medical Science Monitor ◽

10.12659/msm.920278 ◽

2020 ◽

Vol 26 ◽

Author(s):

Yi Ming ◽

Youmin Yin ◽

Zhaoli Sun

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Protein Kinase ◽

Nuclear Factor Kappa B ◽

Sirtuin 1 ◽

Nuclear Factor ◽

Group A ◽

Nuclear Receptor Subfamily

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The Effects of Initial Periodontal Therapy on the Serum Receptor Activator of Nuclear Factor-κβ Ligand/Osteoprotegerin System in Patients With Type 2 Diabetes Mellitus and Periodontitis

Journal of Periodontology ◽

10.1902/jop.2015.150480 ◽

2016 ◽

Vol 87 (3) ◽

pp. 303-311 ◽

Author(s):

Jing Ling Xu ◽

Huan Xin Meng ◽

Lu He ◽

Xian E. Wang ◽

Lin Zhang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Periodontal Therapy ◽

Nuclear Factor ◽

Receptor Activator

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A Novel Dominant-Negative Mutation of the Hepatocyte Nuclear Factor-1α Gene in Japanese Early-Onset Type 2 Diabetes

Hormone and Metabolic Research ◽

10.1055/s-2007-978656 ◽

2000 ◽

Vol 32 (09) ◽

pp. 373-377 ◽

Author(s):

S. Tanaka ◽

T. Kobayashi ◽

H. Tomura ◽

M. Okubo ◽

K. Nakanishi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Early Onset ◽

Dominant Negative ◽

Nuclear Factor ◽

Hepatocyte Nuclear Factor ◽

Dominant Negative Mutation ◽

Hepatocyte Nuclear Factor 1Α

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