scholarly journals Crystal Structure of the Mp1p Ligand Binding Domain 2 Reveals Its Function as a Fatty Acid-binding Protein

2010 ◽  
Vol 285 (12) ◽  
pp. 9211-9220 ◽  
Author(s):  
Shuang Liao ◽  
Edward T. K. Tung ◽  
Wei Zheng ◽  
Ken Chong ◽  
Yuanyuan Xu ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Fatty Acid ◽  
Ligand Binding ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Effect on ligand binding of arginine mutations in recombinant rat liver fatty acid-binding protein

1994 ◽  
Vol 297 (1) ◽  
pp. 103-107 ◽  
Author(s):  
A E Thumser ◽  
C Evans ◽  
A F Worrall ◽  
D C Wilton
Keyword(s):  
Fatty Acid ◽  
Ligand Binding ◽  
Rat Liver ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Liver Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Wide Range ◽  
Arginine Residues

Rat liver fatty acid-binding protein is able to accommodate a wide range of non-polar anions in addition to long-chain fatty acids. The two arginine residues of rat liver fatty acid-binding protein, Arg122 and Arg126, have been mutated and the effect of mutation on ligand binding investigated. No significant decrease in affinity for the fluorescent fatty acid analogue, 11-(5-dimethylaminonaphthalenesulphonyl amino)undecanoic acid, or oleate was observed. However, the apparent affinity for oleoyl-CoA was slightly increased with the mutations Ala122 and Gln122 such that oleoyl-CoA rather than oleate became the preferred ligand for these mutants. Small changes in protein stability were observed with the Arg122 mutations. The lack of notable ionic involvement of the conserved internal residue Arg122 in ligand binding is consistent with the hypothesis that the mode of ligand binding in liver fatty acid-binding protein is markedly different from that of other members of this lipid-binding protein family.

The crystal structure of Echinococcus granulosus fatty-acid-binding protein 1

2003 ◽  
Vol 1649 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Emma Jakobsson ◽  
Gabriela Alvite ◽  
Terese Bergfors ◽  
Adriana Esteves ◽  
Gerard J. Kleywegt
Keyword(s):  
Crystal Structure ◽  
Fatty Acid ◽  
Echinococcus Granulosus ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Crystal Structure and Thermodynamic Analysis of Human Brain Fatty Acid-binding Protein

2000 ◽  
Vol 275 (35) ◽  
pp. 27045-27054
Author(s):  
Ganesaratnam K. Balendiran ◽  
Frank Schnütgen ◽  
Giovanna Scapin ◽  
Torsten Börchers ◽  
Ning Xhong ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Fatty Acid ◽  
Human Brain ◽  
Thermodynamic Analysis ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Crystal Structure of Chicken Liver Basic Fatty Acid-Binding Protein Complexed with Cholic Acid†,‡

Biochemistry ◽  
2004 ◽  
Vol 43 (44) ◽  
pp. 14072-14079 ◽  
Author(s):  
Daniele Nichesola ◽  
Massimiliano Perduca ◽  
Stefano Capaldi ◽  
Maria E. Carrizo ◽  
Pier Giorgio Righetti ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Fatty Acid ◽  
Cholic Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Chicken Liver ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Crystal structure of chicken liver basic fatty acid-binding protein at 2.7 � resolution

1990 ◽  
Vol 98 (1-2) ◽  
Author(s):  
Giovanna Scapin ◽  
Paola Spadon ◽  
Mario Mammi ◽  
Giuseppe Zanotti ◽  
HugoL. Monaco
Keyword(s):  
Crystal Structure ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Chicken Liver ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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