scholarly journals Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

2010 ◽  
Vol 286 (5) ◽  
pp. 3717-3728 ◽  
Author(s):  
Lan-Feng Dong ◽  
Victoria J. A. Jameson ◽  
David Tilly ◽  
Jiri Cerny ◽  
Elahe Mahdavian ◽  
...  
Keyword(s):  
Vitamin E ◽  
Mitochondrial Targeting ◽  
Mitochondrial Complex ◽  
Vitamin E Succinate ◽  
Complex Ii ◽  
Anti Cancer ◽  
Cancer Activity

Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes

2017 ◽  
Vol 35 (3) ◽  
pp. 174-186 ◽  
Author(s):  
Ahmad Salimi ◽  
Mehryar Habibi Roudkenar ◽  
Enayatollah Seydi ◽  
Leila Sadeghi ◽  
Alireza Mohseni ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Mitochondrial Complex ◽  
Selective Toxicity ◽  
Complex Ii ◽  
Anti Cancer ◽  
Cancer Agent

scholarly journals Anti-Cancer Effects of Sulfasalazine and Vitamin E Succinate in MDA-MB 231 Triple-Negative Breast Cancer Cells

2019 ◽  
Vol 16 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Chyou-Wei Wei ◽  
Yung-Luen Yu ◽  
Ji-Ying Lu ◽  
Yu-Ting Hung ◽  
Hsiao-Chun Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin E ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Vitamin E Succinate ◽  
Anti Cancer

scholarly journals Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

2020 ◽  
Vol 56 (34) ◽  
pp. 4672-4675 ◽  
Author(s):  
Alexander R. Nödling ◽  
Emily M. Mills ◽  
Xuefei Li ◽  
Davide Cardella ◽  
Edward J. Sayers ◽  
...  
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Cyanine Dye ◽  
Mitochondrial Targeting ◽  
Anti Cancer ◽  
Cancer Activity

Conjugation of small molecules to a simple cyanine dye can lead to organelle-specific delivery.

542 The Experimental Anti-cancer Drug Mitochondrially-targeted Vitamin E Succinate Inhibits Mitochondrial Transcription

2012 ◽  
Vol 48 ◽  
pp. 167
Author(s):  
J. Rohlena ◽  
J. Truksa ◽  
L. Dong ◽  
M. Vondrusova ◽  
K. Kluckova ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cancer Drug ◽  
Vitamin E Succinate ◽  
Mitochondrial Transcription ◽  
Anti Cancer

scholarly journals Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Bing Yan ◽  
Marina Stantic ◽  
Renata Zobalova ◽  
Ayenachew Bezawork-Geleta ◽  
Michael Stapelberg ◽  
...  
Keyword(s):  
Vitamin E ◽  
Breast Tumour ◽  
Dependent Manner ◽  
Vitamin E Succinate ◽  
Complex Ii

scholarly journals Mitochondrial complex II, a novel target for anti-cancer agents

2013 ◽  
Vol 1827 (5) ◽  
pp. 552-564 ◽  
Author(s):  
Katarina Kluckova ◽  
Ayanachew Bezawork-Geleta ◽  
Jakub Rohlena ◽  
Lanfeng Dong ◽  
Jiri Neuzil
Keyword(s):  
Mitochondrial Complex ◽  
Complex Ii ◽  
Anti Cancer ◽  
Novel Target

scholarly journals A Co-Delivery Strategy of Abemaciclib Combined with Vitamin E Succinate Based on Hyaluronic Acid Modified Calcium Phosphate to Enhance the Anti-Cancer Effect

2021 ◽  
Author(s):  
Yuanyuan Liu ◽  
Na Gan ◽  
Shuangshuang Zhang ◽  
Qiaomei Sun ◽  
Xin Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vitamin E ◽  
Calcium Phosphate ◽  
Synergistic Effects ◽  
Hollow Structure ◽  
Inhibitory Effect ◽  
Vitamin E Succinate ◽  
Delivery Strategy ◽  
Anti Cancer ◽  
High Doses

Abstract Combination therapy including anticancer drugs usually induces synergistic effects, especially in combination with natural compounds as a chemical sensitizer. Nano-based drug delivery technology is also effective in solving the toxicity of single drugs at high doses. In this study, we established a co-delivery strategy for abemaciclib (ABE) combined with vitamin E succinate (VES) based on HA-modified calcium phosphate (CaP) nanomaterials to enhance anti-cancer effect. The nano-sized HA/CaP particles (90 nm) have a hollow structure. Surprisingly, after modification with HA, HA/CaP has more pH sensitivity. CaP released 30% ABE and 91% VES at pH 7.4, whereas HA/CaP vsreleased 14% ABE and 32% VES at the same pH. Cell experiments showed that HA/CaP/ABE-VES had stronger cell inhibitory effect on MCF-7 compared with CaP/ABE-VES. This inorganic/organic composite for the co-delivery of ABE and VES has obvious tumor inhibition effect, and is ideal for anti-tumor drug delivery.

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II

2007 ◽  
Vol 39 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Jiri Neuzil ◽  
Jeffrey C. Dyason ◽  
Ruth Freeman ◽  
Lan-Feng Dong ◽  
Lubomir Prochazka ◽  
...  
Keyword(s):  
Vitamin E ◽  
Complex Ii ◽  
Anti Cancer
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