scholarly journals Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

2013 ◽  
Vol 288 (13) ◽  
pp. 8922-8934 ◽  
Author(s):  
Márton Megyeri ◽  
Veronika Harmat ◽  
Balázs Major ◽  
Ádám Végh ◽  
Júlia Balczer ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Lectin Pathway ◽  
Quantitative Characterization ◽  
Mannan Binding Lectin ◽  
Binding Lectin

The Role of Mannan Binding Lectin Pathway in Non-Alcoholic Fatty Liver Disease (NAFLD)

2014 ◽  
Vol 109 ◽  
pp. S168
Author(s):  
Azza Karrar ◽  
Siddharth Hariharan ◽  
Khatera Malik ◽  
Zheng Li ◽  
Munkhzul Otgonsuren ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Lectin Pathway ◽  
Alcoholic Fatty Liver ◽  
Mannan Binding Lectin ◽  
Binding Lectin ◽  
Alcoholic Fatty Liver Disease

scholarly journals Identification of the Site of Human Mannan-Binding Lectin Involved in the Interaction with Its Partner Serine Proteases: The Essential Role of Lys55

2007 ◽  
Vol 178 (9) ◽  
pp. 5710-5716 ◽  
Author(s):  
Florence Teillet ◽  
Monique Lacroix ◽  
Steffen Thiel ◽  
Dietmar Weilguny ◽  
Teit Agger ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Essential Role ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Characterization of the Interaction Between L-Ficolin/P35 and Mannan-Binding Lectin-Associated Serine Proteases-1 and -2

2002 ◽  
Vol 169 (10) ◽  
pp. 5735-5743 ◽  
Author(s):  
Sandor Cseh ◽  
Loanys Vera ◽  
Misao Matsushita ◽  
Teizo Fujita ◽  
Gérard J. Arlaud ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation

Structure ◽  
2017 ◽  
Vol 25 (2) ◽  
pp. 364-375 ◽  
Author(s):  
Ruodan Nan ◽  
Christopher M. Furze ◽  
David W. Wright ◽  
Jayesh Gor ◽  
Russell Wallis ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Lectin Pathway ◽  
Pathway Activation ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Purification and Characterization of a Mannan-Binding Lectin Specifically Expressed in Corms of Saffron Plant (CrocussativusL.)

2000 ◽  
Vol 48 (2) ◽  
pp. 457-463 ◽  
Author(s):  
Julio Escribano ◽  
Angela Rubio ◽  
Manuel Alvarez-Ortí ◽  
Antonio Molina ◽  
José A. Fernández
Keyword(s):  
Purification And Characterization ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Quantitative characterization of the autoactivation steps of MASP-1 and -2: Toward a kinetic model of lectin pathway activation

2011 ◽  
Vol 48 (14) ◽  
pp. 1668-1669
Author(s):  
J. Dobó ◽  
M. Megyeri ◽  
K. Szilágyi ◽  
V. Harmat ◽  
P. Závodszky ◽  
...  
Keyword(s):  
Kinetic Model ◽  
Lectin Pathway ◽  
Quantitative Characterization ◽  
Pathway Activation

Mannose-binding lectin genetics: from A to Z

2008 ◽  
Vol 36 (6) ◽  
pp. 1461-1466 ◽  
Author(s):  
Peter Garred
Keyword(s):  
Epidemiological Studies ◽  
Mannose Binding Lectin ◽  
Host Cells ◽  
Lectin Pathway ◽  
Mannose Binding ◽  
The Stability ◽  
Genetically Determined ◽  
Micro Organisms ◽  
Binding Lectin

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein. It binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. Common variant alleles situated both in promoter and structural regions of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variations in MBL serum concentrations influence the susceptibility to and the course of different types of infectious, autoimmune, neoplastic, metabolic and cardiovascular diseases, but this is still a subject under discussion. The fact that these genetic variations are very frequent, indicates a dual role of MBL. This overview summarizes the current molecular understanding of human MBL2 genetics.

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