scholarly journals Caenorhabditis elegansRecognizes a Bacterial Quorum-sensing Signal Molecule through the AWCONNeuron

2014 ◽  
Vol 289 (38) ◽  
pp. 26566-26573 ◽  
Author(s):  
Kristen M. Werner ◽  
Lark J. Perez ◽  
Rajarshi Ghosh ◽  
Martin F. Semmelhack ◽  
Bonnie L. Bassler
Keyword(s):  
Quorum Sensing ◽  
Signal Molecule ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals l-Canavanine Made by Medicago sativa Interferes with Quorum Sensing in Sinorhizobium meliloti

2005 ◽  
Vol 187 (24) ◽  
pp. 8427-8436 ◽  
Author(s):  
Neela D. Keshavan ◽  
Puneet K. Chowdhary ◽  
Donovan C. Haines ◽  
Juan E. González
Keyword(s):  
Quorum Sensing ◽  
Medicago Sativa ◽  
Sinorhizobium Meliloti ◽  
Signal Molecules ◽  
Bacterial Strains ◽  
Signal Molecule ◽  
Gram Negative ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Regulated Gene Expression

ABSTRACT Sinorhizobium meliloti is a gram-negative soil bacterium, capable of establishing a nitrogen-fixing symbiosis with its legume host, alfalfa (Medicago sativa). Quorum sensing plays a crucial role in this symbiosis, where it influences the nodulation process and the synthesis of the symbiotically important exopolysaccharide II (EPS II). S. meliloti has three quorum-sensing systems (Sin, Tra, and Mel) that use N-acyl homoserine lactones as their quorum-sensing signal molecule. Increasing evidence indicates that certain eukaryotic hosts involved in symbiotic or pathogenic relationships with gram-negative bacteria produce quorum-sensing-interfering (QSI) compounds that can cross-communicate with the bacterial quorum-sensing system. Our studies of alfalfa seed exudates suggested the presence of multiple signal molecules capable of interfering with quorum-sensing-regulated gene expression in different bacterial strains. In this work, we choose one of these QSI molecules (SWI) for further characterization. SWI inhibited violacein production, a phenotype that is regulated by quorum sensing in Chromobacterium violaceum. In addition, this signal molecule also inhibits the expression of the S. meliloti exp genes, responsible for the production of EPS II, a quorum-sensing-regulated phenotype. We identified this molecule as l-canavanine, an arginine analog, produced in large quantities by alfalfa and other legumes.

scholarly journals Bacterial quorum sensing and the role of algae in bacterial diseases control in aquaculture

2010 ◽  
Vol 9 (2) ◽  
pp. 110 ◽  
Author(s):  
. Wiyoto ◽  
Julie Ekasari
Keyword(s):  
Quorum Sensing ◽  
Disease Control ◽  
Target Gene ◽  
Communication Process ◽  
Bacterial Disease ◽  
Signal Molecule ◽  
Bacterial Diseases ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

<p>Bacterial disease is one of the most common diseases in aquaculture practices which have a significant impact. Several researches noted that pathogenicity of a certain bacteria can be determined by its quorum sensing activity. Quorum sensing is a communication process of a certain bacteria with the same or different species of bacteria which involves the releasing and capturing of signal molecule to and from the environment. This activity will activate a certain target gene which further resulted in the expression of a phenotype by the bacteria. With regard to this characteristic, one of the methods to control bacterial diseases is by quorum sensing disruption. Several species of algae, both micro and macro, have been found to be able to intervense bacterial quorum sensing and thus can be used as an alternative in bacterial disease control.   </p> <p>Key words: quorum sensing, bacterial disease, aquaculture, algae</p> <p> </p><p>Abstrak</p> <p>Penyakit bakteri adalah salah satu penyakit yang paling umum dalam akuakultur dengan dampak yang cukup signifikan. Beberapa penelitian menunjukkan bahwa tingkat patogenitas suatu bakteri salah satunya ditentukan oleh aktivitas kuorum sensing bakteri. Kuorum sensing bakteri merupakan suatu proses komunikasi yang dilakukan oleh bakteri dengan bakteri lainnya baik yang sejenis maupun berlainan jenis yang berupa pelepasan dan penangkapan molekul sinyal menuju dan dari lingkungan sekitar bakteri tersebut. Aktivitas inilah yang akan menentukan ekspresi suatu gen target seperti patogenitas, sehingga salah satu metode yang dapat digunakan dalam mengendalikan penyakit yang disebabkan oleh bakteri adalah dengan mengganggu aktivitas kuorum sensing bakteri. Beberapa jenis alga, baik mikro maupun makro, diketahui dapat mengintervensi aktivitas kuorum sensing, dan dapat menjadi salah satu alternatif bagi pengendalian penyakit bakterial.</p> <p>Kata-kata kunci: kuorum sensing, penyakit bakterial, akuakultur, alga</p>

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