scholarly journals A Rapid Increase in the Total Number of Cell Surface Functional GABAA Receptors Induced by Brain-derived Neurotrophic Factor in Rat Visual Cortex

2003 ◽  
Vol 278 (45) ◽  
pp. 44097-44102 ◽  
Author(s):  
Yoshito Mizoguchi ◽  
Takashi Kanematsu ◽  
Masato Hirata ◽  
Junichi Nabekura
Keyword(s):  
Visual Cortex ◽  
Cell Surface ◽  
Gabaa Receptors ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

Monocular deprivation decreases the expression of messenger RNA for brain-derived neurotrophic factor in the rat visual cortex

Neuroscience ◽  
1995 ◽  
Vol 69 (4) ◽  
pp. 1133-1144 ◽  
Author(s):  
Y. Bozzi ◽  
T. Pizzorusso ◽  
F. Cremisi ◽  
F.M. Rossi ◽  
G. Barsacchi ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Neurotrophic Factor ◽  
Messenger Rna ◽  
Brain Derived Neurotrophic Factor ◽  
Monocular Deprivation

Brain-derived neurotrophic factor blocks long-term depression in rat visual cortex

1996 ◽  
Vol 76 (6) ◽  
pp. 4198-4201 ◽  
Author(s):  
Y. Akaneya ◽  
T. Tsumoto ◽  
H. Hatanaka
Keyword(s):  
Visual Cortex ◽  
Neurotrophic Factor ◽  
Tyrosine Kinases ◽  
Low Frequency ◽  
Long Term Potentiation ◽  
Brain Derived Neurotrophic Factor ◽  
Long Term Depression ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation

1. Brain-derived neurotrophic factor (BDNF) has been reported to play a role in long-term potentiation (LTP) in hippocampus, but whether it is involved also in long-term depression (LTD) is not yet known. In this study, we tested whether BDNF and its gene family, nerve growth factor (NGF), have any effect on synaptic transmission and LTD in visual cortical slices of young rats. 2. An application of BDNF at the concentration of 20 ng/ml did not significantly change layer II/III field responses evoked by layer IV stimulation at 0.1 Hz, although at 200 ng/ml it enhanced responses. BDNF at 20 ng/ml prevented LTD of field responses from being induced by low-frequency stimulation (1 Hz for 15 min) of layer IV. NGF did not have such effects in the same concentration range as that of BDNF. 3. The action of BDNF was antagonized by K252a, an inhibitor of receptor tyrosine kinases. When K252a alone was applied to slices, LTD of stronger magnitude than in control slices was induced by low-frequency stimulation. 4. These results suggest that endogeneous BDNF may prevent synapses from being depressed by low-frequency inputs in the developing visual cortex.

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