scholarly journals Brain-Derived Neurotrophic Factor Modulates Fast Synaptic Inhibition by Regulating GABAA Receptor Phosphorylation, Activity, and Cell-Surface Stability

2004 ◽  
Vol 24 (2) ◽  
pp. 522-530 ◽  
Author(s):  
J. N. Jovanovic
Keyword(s):  
Cell Surface ◽  
Gabaa Receptor ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Synaptic Inhibition ◽  
Receptor Phosphorylation ◽  
Surface Stability

scholarly journals Regulation of TrkB cell surface expression—a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor

2020 ◽  
Vol 382 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Thomas Andreska ◽  
Patrick Lüningschrör ◽  
Michael Sendtner
Keyword(s):  
Cell Surface ◽  
Neurotrophic Factor ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Surface Expression ◽  
Brain Derived Neurotrophic Factor ◽  
Fine Tuning ◽  
Cell Surface Expression ◽  
Rapid Modulation ◽  
And Function

Abstract Neurotrophin signaling via receptor tyrosine kinases is essential for the development and function of the nervous system in vertebrates. TrkB activation and signaling show substantial differences to other receptor tyrosine kinases of the Trk family that mediate the responses to nerve growth factor and neurotrophin-3. Growing evidence suggests that TrkB cell surface expression is highly regulated and determines the sensitivity of neurons to brain-derived neurotrophic factor (BDNF). This translocation of TrkB depends on co-factors and modulators of cAMP levels, N-glycosylation, and receptor transactivation. This process can occur in very short time periods and the resulting rapid modulation of target cell sensitivity to BDNF could represent a mechanism for fine-tuning of synaptic plasticity and communication in complex neuronal networks. This review focuses on those modulatory mechanisms in neurons that regulate responsiveness to BDNF via control of TrkB surface expression.

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