scholarly journals The Crystal Structure of Placental Growth Factor in Complex with Domain 2 of Vascular Endothelial Growth Factor Receptor-1

2003 ◽  
Vol 279 (11) ◽  
pp. 10382-10388 ◽  
Author(s):  
Hans W. Christinger ◽  
Germaine Fuh ◽  
Abraham M. de Vos ◽  
Christian Wiesmann
Keyword(s):  
Crystal Structure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Placental Growth Factor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

Structure ◽  
1999 ◽  
Vol 7 (3) ◽  
pp. 319-330 ◽  
Author(s):  
Michele A McTigue ◽  
John A Wickersham ◽  
Chris Pinko ◽  
Richard E Showalter ◽  
Camran V Parast ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Kinase Domain ◽  
Vascular Endothelial ◽  
Key Enzyme ◽  
Endothelial Growth Factor

scholarly journals Crystal structure, Hirshfeld analysis and molecular docking with the vascular endothelial growth factor receptor-2 of (3Z)-5-fluoro-3-(hydroxyimino)indolin-2-one

2017 ◽  
Vol 73 (7) ◽  
pp. 987-992 ◽  
Author(s):  
Bianca Barreto Martins ◽  
Leandro Bresolin ◽  
Renan Lira de Farias ◽  
Adriano Bof de Oliveira ◽  
Vanessa Carratu Gervini
Keyword(s):  
Crystal Structure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Title Compound ◽  
Crystal Packing ◽  
Growth Factor Receptor ◽  
Hydroxylamine Hydrochloride ◽  
Vascular Endothelial ◽  
Compound C ◽  
Endothelial Growth Factor

The reaction between 5-fluoroisatin and hydroxylamine hydrochloride in acidic ethanol yields the title compound, C8H5FN2O2, whose molecular structure matches the asymmetric unit and is nearly planar with an r.m.s. deviation for the mean plane through all non-H atoms of 0.0363 Å. In the crystal, the molecules are linked by N—H...N, N—H...O and O—H...O hydrogen-bonding interactions into a two-dimensional network along the (100) plane, forming rings withR22(8) andR12(5) graph-set motifs. The crystal packing also features weak π–π interactions along the [100] direction [centroid-to-centroid distance 3.9860 (5) Å]. Additionally, the Hirshfeld surface analysis indicates that the major contributions for the crystal structure are the O...H (28.50%) and H...F (16.40%) interactions. Anin silicoevaluation of the title compound with the vascular endothelial growth factor receptor-2 (VEGFR-2) was carried out. The title compound and the selected biological target VEGFR-2 show the N—H...O(GLU94), (CYS96)N—H...O(isatine) and (PHE95)N—H...O(isatine) intermolecular interactions, which suggests a solid theoretical structure–activity relationship.

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