scholarly journals Thrombin Induces Tumor Invasion through the Induction and Association of Matrix Metalloproteinase-9 and β1-Integrin on the Cell Surface

2007 ◽  
Vol 283 (5) ◽  
pp. 2822-2834 ◽  
Author(s):  
A. Reza Radjabi ◽  
Kenjiro Sawada ◽  
Sujatha Jagadeeswaran ◽  
Alfred Eichbichler ◽  
Hilary A. Kenny ◽  
...  
Keyword(s):  
Cell Surface ◽  
Matrix Metalloproteinase ◽  
Tumor Invasion ◽  
Matrix Metalloproteinase 9 ◽  
Β1 Integrin ◽  
Metalloproteinase 9

scholarly journals Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 ◽  
Vol 14 (2) ◽  
pp. 163-176 ◽  
Author(s):  
Qin Yu ◽  
Ivan Stamenkovic
Keyword(s):  
Cell Surface ◽  
Matrix Metalloproteinase ◽  
Tumor Invasion ◽  
Physiological Mechanism ◽  
Tissue Remodeling ◽  
Matrix Metalloproteinase 9 ◽  
Promote Tumor Growth ◽  
The Matrix ◽  
Β Function ◽  
Metalloproteinase 9

We have uncovered a novel functional relationship between the hyaluronan receptor CD44, the matrix metalloproteinase-9 (MMP-9) and the multifunctional cytokine TGF-β in the control of tumor-associated tissue remodeling. CD44 provides a cell surface docking receptor for proteolytically active MMP-9 and we show here that localization of MMP-9 to cell surface is required for its ability to promote tumor invasion and angiogenesis. Our observations also indicate that MMP-9, as well as MMP-2, proteolytically cleaves latent TGF-β, providing a novel and potentially important mechanism for TGF-β activation. In addition, we show that MMP-9 localization to the surface of normal keratinocytes is CD44 dependent and can activate latent TGF-β. These observations suggest that coordinated CD44, MMP-9, and TGF-β function may provide a physiological mechanism of tissue remodeling that can be adopted by malignant cells to promote tumor growth and invasion.

scholarly journals Withdrawal: Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of β1-integrin, ERK, and NF-κB.

2020 ◽  
Vol 295 (45) ◽  
pp. 15426-15426
Author(s):  
Praveen Bhoopathi ◽  
Chandramu Chetty ◽  
Sateesh Kunigal ◽  
Sravan K. Vanamala ◽  
Jasti S. Rao ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Tumor Growth ◽  
Matrix Metalloproteinase 9 ◽  
Β1 Integrin ◽  
Sequential Activation ◽  
Metalloproteinase 9

Abeta(1–40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP

2007 ◽  
Vol 28 (3) ◽  
pp. 304-315 ◽  
Author(s):  
Argiris A. Talamagas ◽  
Spiros Efthimiopoulos ◽  
Effie C. Tsilibary ◽  
Maria E. Figueiredo-Pereira ◽  
Athina K. Tzinia
Keyword(s):  
Cell Surface ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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