Venous access care in home parenteral nutrition.

2014 ◽  
pp. 308-317
Author(s):  
G. Scoppettuolo ◽  
M. Pittiruti
2011 ◽  
Vol 35 (5) ◽  
pp. 588-596 ◽  
Author(s):  
Getty Huisman-de Waal ◽  
Michelle Versleijen ◽  
Theo van Achterberg ◽  
Jan B. Jansen ◽  
Hans Sauerwein ◽  
...  

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 439
Author(s):  
Dane Christina Daoud ◽  
Geert Wanten ◽  
Francisca Joly

Catheter-related bloodstream infection (CRBSI) is one of the most common and potentially fatal complications in patients receiving home parenteral nutrition (HPN). In order to prevent permanent venous access loss, catheter locking with an antimicrobial solution has received significant interest and is often a favored approach as part of the treatment of CRBSI, but mainly for its prevention. Several agents have been used for treating and preventing CRBSI, for instance antibiotics, antiseptics (ethanol, taurolidine) and, historically, anticoagulants such as heparin. Nonetheless, current guidelines do not provide clear guidance on the use of catheter locks. Therefore, this review aims to provide a better understanding of the current use of antimicrobial locking in patients on HPN as well as reviewing the available data on novel compounds. Despite the fact that our current knowledge on catheter locking is still hampered by several gaps, taurolidine and ethanol solutions seem promising for prevention and potentially, but not proven, treatment of CRBSI. Additional studies are warranted to further characterize the efficacy and safety of these agents.


Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1165 ◽  
Author(s):  
Jessica Noelting ◽  
Brian Jurewitsch ◽  
Johane Allard

Patients on home parenteral nutrition (HPN) are dependent on central venous access for long-term sustenance, and catheter-related bloodstream infections (CRBSIs) are a major cause of morbidity and mortality in this patient population. As such, there is much interest in finding new methods for preventing CRBSIs in patients on HPN. As it is thought that these infections are preceded by microbial colonization of the catheter, one approach is to use antimicrobial catheter lock solutions. Although antibiotic catheter lock solutions have been present for decades, their use has been mostly limited to the treatment of CRBSIs due to concern for promoting microbial resistance. Recently, however, with the advent of non-antibiotic antimicrobial catheter lock solutions, this approach is gaining popularity as a promising method to decrease rates of CRBSI in HPN patients.


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