scholarly journals Non-Antibiotic Antimicrobial Catheter Lock Solutions in Patients on Home Parenteral Nutrition

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1165 ◽  
Author(s):  
Jessica Noelting ◽  
Brian Jurewitsch ◽  
Johane Allard
Keyword(s):  
Parenteral Nutrition ◽  
Central Venous Access ◽  
Bloodstream Infections ◽  
Venous Access ◽  
Home Parenteral Nutrition ◽  
Microbial Colonization ◽  
Central Venous ◽  
New Methods ◽  
Catheter Lock

Patients on home parenteral nutrition (HPN) are dependent on central venous access for long-term sustenance, and catheter-related bloodstream infections (CRBSIs) are a major cause of morbidity and mortality in this patient population. As such, there is much interest in finding new methods for preventing CRBSIs in patients on HPN. As it is thought that these infections are preceded by microbial colonization of the catheter, one approach is to use antimicrobial catheter lock solutions. Although antibiotic catheter lock solutions have been present for decades, their use has been mostly limited to the treatment of CRBSIs due to concern for promoting microbial resistance. Recently, however, with the advent of non-antibiotic antimicrobial catheter lock solutions, this approach is gaining popularity as a promising method to decrease rates of CRBSI in HPN patients.

Tip Position of Long-Term Central Venous Access Devices Used for Parenteral Nutrition

2007 ◽  
Vol 31 (5) ◽  
pp. 382-387 ◽  
Author(s):  
Robert DeChicco ◽  
Douglas L. Seidner ◽  
Carlos Brun ◽  
Ezra Steiger ◽  
Judy Stafford ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Central Venous Access ◽  
Venous Access ◽  
Central Venous ◽  
Tip Position ◽  
Venous Access Devices

Central venous thrombosis in patients receiving long-term parenteral nutrition

2008 ◽  
Vol 33 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Donald R. Duerksen
Keyword(s):  
Parenteral Nutrition ◽  
Venous Thrombosis ◽  
Vitamin K ◽  
Central Venous Access ◽  
Anticoagulation Therapy ◽  
Venous Catheter ◽  
Venous Access ◽  
Central Venous ◽  
Central Venous Thrombosis

Long-term parenteral nutrition (PN) is administered to patients who are unable to use their gastrointestinal tract to absorb sufficient nutrients and water to maintain their nutritional status. Patients receiving long-term parenteral nutrition are at risk of numerous complications including thrombosis of the central venous catheter used to provide nutrition. Central venous access is essential to the successful delivery of long-term PN. One of the strategies to lessen the frequency of this complication is anticoagulation therapy with warfarin. The effect of warfarin in preventing this complication may be modified by vitamin K intake. Individuals with gastrointestinal failure may receive vitamin K from a variety of sources. This review summarizes the role of warfarin in preventing central venous access thrombosis. It also summarizes potential sources of vitamin K intake in home parenteral nutrition patients, examines the evidence for recommendations regarding vitamin K intake, and considers the potential impact of increased vitamin K intake on home PN patients, particularly on the prevention of central venous thrombosis.

Thrombosis and embolism in long-term central venous access for parenteral nutrition

The Lancet ◽  
1994 ◽  
Vol 344 (8929) ◽  
pp. 1043-1045 ◽  
Author(s):  
C.M Dollery ◽  
I.D Sullivan ◽  
C Bull ◽  
O Bauraind ◽  
P.J Milla
Keyword(s):  
Parenteral Nutrition ◽  
Central Venous Access ◽  
Venous Access ◽  
Central Venous

scholarly journals Updates in Parenteral Nutrition

2014 ◽  
Vol 21 (3) ◽  
pp. 213-219
Author(s):  
Simona Popescu ◽  
Laura Diaconu ◽  
Bogdan Timar ◽  
Romulus Timar
Keyword(s):  
Amino Acids ◽  
Parenteral Nutrition ◽  
Nutritional Support ◽  
Laboratory Tests ◽  
Central Venous Access ◽  
Venous Access ◽  
Peripheral Vein ◽  
Central Venous ◽  
Additional Approach

AbstractParenteral nutrition (PN) represents an alternative or additional approach when other nutrition routes are not succeeding or when using other routes is not possible or would be unsafe. The main goal of PN is to deliver a nutrient mixture closely related to requirements in a safe manner and without complications. The concentration of parenteral solutions (PS) determines their osmolarity, according to which, the solutions will be infused by peripheral or central venous access. The solutions used in central PN contain more glucose, which, together with amino acids and electrolytes, determines a hyperosmolar solution, which has to be administered in a large caliber vein. Central venous access may be maintained over long periods of time. In peripheral PN there are used solutions with a lower concentration of dextrose in order to obtain (solutions with the) an osmolarity lower than 900 mOsm/L, which can be administered in a peripheral vein. Peripheral PN is used over short periods of time because of the limited tolerance for a long term of peripheral veins. PN is an efficient method to ensure the nutritional support which can be associated with numerous complications, some of them severe, with lethal potential. Patients with PN need a daily physical examination and laboratory tests.

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