Apparent lack of vertical transmission of simian immunodeficiency virus (SIV) in naturally infected African green monkeys, Cercopithecus aethiops

1995 ◽  
Vol 89 (5) ◽  
pp. 573-576 ◽  
Author(s):  
M. G. Otsyula ◽  
Agegnehu Gettie ◽  
M. Suleman ◽  
E. Muthoni ◽  
R. Tarara ◽  
...  
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Vertical Transmission ◽  
Cercopithecus Aethiops ◽  
Apparent Lack ◽  
Immunodeficiency Virus ◽  
Green Monkeys

The U3 Promoter and the nef Gene of Simian Immunodeficiency Virus (SIV) smmPBj1.9 Do Not Confer Acute Pathogenicity upon SIVagm

1998 ◽  
Vol 72 (4) ◽  
pp. 3446-3450 ◽  
Author(s):  
Stefan Wagener ◽  
Matthias T. Dittmar ◽  
Brigitte Beer ◽  
Renate König ◽  
Roland Plesker ◽  
...  
Keyword(s):  
Simian Immunodeficiency Virus ◽  
The Other ◽  
Cercopithecus Aethiops ◽  
Macaca Nemestrina ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Immunodeficiency Virus ◽  
Genomic Regions ◽  
Green Monkeys ◽  
Chimeric Viruses

ABSTRACT Two chimeric proviruses comprising the U3 promoter and thenef gene of simian immunodeficiency virus (SIV) smmPBj1.9 in addition to other genomic regions of SIVagm3mc from African green monkeys (Cercopithecus aethiops) were constructed. The derived chimeric viruses (SIVagm3mc/SIVsmmPBj1.9) were both able to replicate in nonstimulated peripheral blood leukocytes from pig-tailed macaques (Macaca nemestrina), a biological property often correlated with acute pathogenicity. However, only one of the chimeric viruses was acutely pathogenic, inducing a rapid depletion of the peripheral CD4+ T cells in two infected pig-tailed macaques within 10 days after infection in a manner similar to infection with SIVsmmPBj1.9 itself. The other chimeric virus actively replicated during the first 8 weeks after experimental infection of two pig-tailed macaques but induced neither acute disease nor CD4+ T-cell depletion for 113 weeks after infection. Thus, the U3 promoter and thenef gene of SIVsmmPBj1.9 alone appear to be insufficient to confer acute pathogenicity to SIVagm3mc.

scholarly journals Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

2017 ◽  
Vol 23 (11) ◽  
pp. 1277-1286 ◽  
Author(s):  
Nicolas Huot ◽  
Beatrice Jacquelin ◽  
Thalia Garcia-Tellez ◽  
Philippe Rascle ◽  
Mickaël J Ploquin ◽  
...  
Keyword(s):  
Lymph Node ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Killer Cells ◽  
Immunodeficiency Virus ◽  
And Control ◽  
Green Monkeys
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