Green and highly efficient synthesis of pyranopyrazoles in choline chloride/urea deep eutectic solvent

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media. Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points. Results: Various products were obtained in good to excellent yields under reaction conditions. Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.

Download Full-text

Urea decomposition: Efficient synthesis of pyrroles using the deep eutectic solvent choline chloride/urea

Tetrahedron Letters ◽

10.1016/j.tetlet.2018.03.043 ◽

2018 ◽

Vol 59 (18) ◽

pp. 1698-1701 ◽

Cited By ~ 7

Author(s):

Lanfang Hu ◽

Juan Luo ◽

Dan Lu ◽

Qiang Tang

Keyword(s):

Choline Chloride ◽

Deep Eutectic Solvent ◽

Efficient Synthesis ◽

Urea Decomposition

Download Full-text

Efficient synthesis of a novel series of indeno-fused pyrido[2,3-d]pyrimidines using a deep eutectic solvent system comprised of choline chloride/urea

Journal of Chemical Research ◽

10.3184/175815517x14981249895596 ◽

2017 ◽

Vol 41 (7) ◽

pp. 430-433

Author(s):

Mohammad Hakimi Roknabadi ◽

Mohammad Hossein Mosslemin ◽

Razieh Mohebat

Keyword(s):

Choline Chloride ◽

Deep Eutectic Solvent ◽

Environmentally Friendly ◽

Solvent System ◽

Efficient Synthesis ◽

Reaction Conditions ◽

Three Component Reaction ◽

High Yields

A series of 13 aryl indeno[2′,1′:5,6]pyrido[2,3- d]pyrimidine-2,4,6-(3 H,5 H,11 H)-triones, eight of which are new, were synthesised regioselectively in high yields by a three-component reaction of 1,3-indanedione, an araldehyde and 6-aminopyrimidin-2,4(1 H,3 H)-dione in the presence of a deep eutectic solvent comprised of choline chloride/urea (1:2) as the catalyst. The reaction conditions were mild and did not require additional catalysts. Given the inexpensive, nontoxic and recyclable nature of the deep eutectic solvent, these reaction conditions are simple to carry out and environmentally friendly.

Download Full-text

A highly efficient microextraction technique based on deep eutectic solvent formed by choline chloride and p-cresol for simultaneous determination of lignans in sesame oils

Food Chemistry ◽

10.1016/j.foodchem.2018.12.088 ◽

2019 ◽

Vol 281 ◽

pp. 140-146 ◽

Cited By ~ 11

Author(s):

Wei Liu ◽

Kangdi Zhang ◽

Guolong Yang ◽

Jingjing Yu

Keyword(s):

Simultaneous Determination ◽

Choline Chloride ◽

Deep Eutectic Solvent ◽

Highly Efficient

Download Full-text

Highly efficient synthesis of pyrazolylphosphonate derivatives in biocompatible deep eutectic solvent

Molecular Catalysis ◽

10.1016/j.mcat.2019.110396 ◽

2019 ◽

Vol 473 ◽

pp. 110396 ◽

Cited By ~ 1

Author(s):

Reddi Mohan Naidu Kalla ◽

Il Kim

Keyword(s):

Deep Eutectic Solvent ◽

Efficient Synthesis ◽

Highly Efficient

Download Full-text

Deep eutectic solvent choline chloride·2CrCl3·6H2O: an efficient catalyst for esterification of formic and acetic acid at room temperature

RSC Advances ◽

10.1039/c6ra01029f ◽

2016 ◽

Vol 6 (26) ◽

pp. 21612-21616 ◽

Cited By ~ 21

Author(s):

Jin Cao ◽

Bin Qi ◽

Jun Liu ◽

Yuhan Shang ◽

Huiwen Liu ◽

...

Keyword(s):

Acetic Acid ◽

Room Temperature ◽

Choline Chloride ◽

Deep Eutectic Solvent ◽

Efficient Catalyst ◽

Selective Method ◽

Highly Efficient

A highly efficient and selective method for esterification of formic and acetic with alcohols has been achieved at room temperature, with chromium based deep eutectic solvent as a catalyst.

Download Full-text

Eutectic Salt Catalyzed Environmentally Benign and Highly Efficient Biginelli Reaction

The Scientific World JOURNAL ◽

10.1100/2012/908702 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Najmadin Azizi ◽

Sahar Dezfuli ◽

Mohmmad Mahmoodi Hahsemi

Keyword(s):

Choline Chloride ◽

Biginelli Reaction ◽

Deep Eutectic Solvent ◽

Reaction Medium ◽

Industrial Applications ◽

Environmentally Benign ◽

Efficient Synthesis ◽

Aliphatic Aldehydes ◽

Eutectic Salt ◽

Tin Chloride

A simple deep eutectic solvent based on tin (II) chloride was used as a dual catalyst and environmentally benign reaction medium for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives, from aromatic and aliphatic aldehydes, 1,3-dicarbonyl compounds, and urea in good-to-excellent yields and short reaction time. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and tin chloride, is relatively inexpensive and recyclable, making it applicable for industrial applications.

Download Full-text