Verification of a cocktail approach for quantitative drug–drug interaction assessment: a comparative analysis between the results of a single drug and a cocktail drug

Xenobiotica ◽  
2021 ◽  
pp. 1-29
Author(s):  
Motoyasu Miura ◽  
Shinya Uchida ◽  
Shimako Tanaka ◽  
Chiaki Kamiya ◽  
Naoki Katayama ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Comparative Analysis ◽  
Single Drug ◽  
Drug Drug Interaction ◽  
Cocktail Approach

scholarly journals Challenges of probe cocktail approach for human drug–drug interaction assays

Bioanalysis ◽  
2018 ◽  
Vol 10 (24) ◽  
pp. 1969-1972 ◽  
Author(s):  
Daniel B Carrão ◽  
Anderson RM de Oliveira ◽  
Igor RS Magalhães
Keyword(s):  
Drug Interaction ◽  
Drug Drug Interaction ◽  
Cocktail Approach

scholarly journals Model-based comparative analysis of rifampicin and rifabutin drug-drug interaction profile

2021 ◽  
Author(s):  
Vianney Tuloup ◽  
Mathilde France ◽  
Romain Garreau ◽  
Nathalie Bleyzac ◽  
Laurent Bourguignon ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interaction ◽  
Comparative Analysis ◽  
Drug Interactions ◽  
Low Dose ◽  
Model Based ◽  
Staphylococcal Infections ◽  
Drug Drug Interaction

ABSTRACT: Rifamycins are widely used for treating mycobacterial and staphylococcal infections. Drug-drug interactions (DDI) caused by rifampicin (RIF) is a major issue. We used a model-based approach to predict the magnitude of DDI with RIF and rifabutin (RBT) for 217 cytochrome P450 (CYP) substrates. On average, DDI caused by low-dose RIF were twice more potent than those caused by RBT. Contrary to RIF, RBT appears unlikely to cause severe DDI, even with sensitive CYP substrates.

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