Quality by design approach for formulation development and evaluation of carboplatin loaded ethylcellulose nanosponges

2021 ◽  
pp. 1-13
Author(s):  
Muhammad Ahsan Hafiz ◽  
Nasir Abbas ◽  
Nadeem Irfan Bukhari
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Formulation Development ◽  
Quality By Design Approach

scholarly journals QUALITY BY DESIGN APPROACH IN FORMULATION DEVELOPMENT AND EVALUATION OF IN SITU OPHTHALMIC GEL OF OLOPATADINE HCL

2019 ◽  
Vol 10 (2) ◽  
pp. 134-142
Author(s):  
Sadhana R Shahi ◽  
Talat Farheen ◽  
Khan Arshiya ◽  
Bhalerao Pravin ◽  
Ade Pavankumar
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Formulation Development ◽  
Quality By Design Approach

scholarly journals Quality-by-Design Approach and Optimization of Risk Factors by Box-Behnken Design in Formulation Development of Aspirin and Glycine Orally Disintegrating Tablet

2021 ◽  
Vol 13 (3) ◽  
pp. 935-950
Author(s):  
R. Kayesh ◽  
M. R. H. Bhuiya ◽  
M. F. Islam ◽  
J. A. Chowdhury
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Formulation Development ◽  
Disintegration Time ◽  
Box Behnken Design ◽  
Orally Disintegrating Tablet ◽  
Quality Profile ◽  
Croscarmellose Sodium ◽  
Quality By Design Approach ◽  
Fmea Method

Quality-by-design approach (QbD) was applied to develop an orally disintegrating tablet (ODT) formulation of aspirin and glycine. At first, the target quality profile and critical quality attributes (CQAs) of the product were identified. Risk assessment was accomplished by failure mode and effects analysis (FMEA) method to assess the factors having a significant effect on CQAs like disintegration time (DT), friability and assay of aspirin and glycine. Low substituted hydroxypropyl cellulose (L-HPC), croscarmellose sodium (CCS) and punch-diameter were found critical for DT and friability. The box-Behnken design was applied to optimize those 3 factors to reach a target DT of ≤ 30 sec. It was found that a punch-diameter between 8.7 ~ 9.3 mm, CCS in a range of 4 % ~ 5 %, and L-HPC in a range of 2 % ~ 8 % produced the best oral disintegrating property and reduced the risk. In summary, this work represented an excellent example of the application of QbD approach in ODT formulation development.

Development of novel cocrystal-based active food packaging by a Quality by Design approach

2021 ◽  
Vol 347 ◽  
pp. 129051
Author(s):  
Federica Bianchi ◽  
Fabio Fornari ◽  
Nicolò Riboni ◽  
Costanza Spadini ◽  
Clotilde Silvia Cabassi ◽  
...  
Keyword(s):  
Food Packaging ◽  
Quality By Design ◽  
Design Approach ◽  
Active Food Packaging ◽  
Quality By Design Approach

A SIMPLE AND SELECTIVE ELECTROCHEMICAL MAGNETO-ASSAY FOR SEA LICE eDNA DETECTION DEVELOPED WITH A QUALITY BY DESIGN APPROACH

2021 ◽  
pp. 148111
Author(s):  
Francesca Bettazzi ◽  
Serena Orlandini ◽  
Luna Zhang ◽  
Serena Laschi ◽  
Mari Mæland Nilsen ◽  
...  
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Sea Lice ◽  
Quality By Design Approach

Quality by design approach in the optimization of the spray-drying process

2011 ◽  
Vol 17 (4) ◽  
pp. 389-397 ◽  
Author(s):  
Arnaud Baldinger ◽  
Lucas Clerdent ◽  
Jukka Rantanen ◽  
Mingshi Yang ◽  
Holger Grohganz
Keyword(s):  
Spray Drying ◽  
Quality By Design ◽  
Design Approach ◽  
Drying Process ◽  
Quality By Design Approach
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