Occam or Hickham? The diagnostic dilemma of an inflammatory brain lesion in the setting of pulmonary aspergillosis and previous neurosurgery

Author(s):  
Louis Onyiriuka ◽  
Kantharuby Tambirajoo ◽  
Susanne Watkins ◽  
Daniel C Walsh
2019 ◽  
Vol 32 (5) ◽  
pp. 335-343
Author(s):  
Ali Alamer ◽  
Donatella Tampieri

Purpose Melanotic schwannoma (MS) was formerly known as a rare variant of schwannoma. The behavior of MS is unpredictable, with a tendency for recurrence and metastasis. The purpose of this study was to illustrate the imaging characteristics of these rare and misdiagnosed tumors. The prognosis of MS is discussed, along with the importance of follow-up exams to assess for recurrence and metastasis. Furthermore, we compare our results with those previously published on MS in order to have a better understanding of this rare entity. Methods Three MS cases were encountered between 2008 and 2015 at our institute. All available data were reviewed, including the clinical history, imaging findings, operative notes, and the histopathology results. A follow-up magnetic resonance imaging (MRI) scan was also reviewed up to 23 months post surgery to assess for recurrence. Results Three cases of MS are included: one in the brain and two in the spine. The brain lesion was in the occipital region. The spine lesions were thoracic intramedullary and sacral intradural. All cases were hypointense on T2-weighted imaging. Gross total resection was achieved for all lesions without adjuvant therapy. To date, the brain lesion recurred 15 months after surgery. Conclusions MS is a rare and distinct entity rather than a variant of schwannoma, and it poses both diagnostic and management dilemmas. Although MS has characteristic MRI features, including T1 and T2 shortening, the preoperative diagnosis is always challenging. Accurate diagnosis is crucial for management planning, including long-term follow-up exams to assess for recurrence and metastasis.


Author(s):  
Philipp Koehler ◽  
P Lewis White ◽  
Paul E Verweij ◽  
Oliver A Cornely

Author(s):  
Kauser Jabeen ◽  
Joveria Farooqi ◽  
Muhammad Irfan ◽  
Syed Ahsan Ali ◽  
David W Denning

2015 ◽  
Vol 122 (2) ◽  
pp. 276-279 ◽  
Author(s):  
Tal Shahar ◽  
Uri Rozovski ◽  
Yuval Shapira ◽  
Erez Nossek ◽  
Bracha Zelikovich ◽  
...  

The differential diagnosis of a brain lesion with two discordant pathology reports includes the presence of collision tumor, metaplastic changes, and labeling errors that occurred during the processing of the specimen. The authors present a case in which the first brain biopsy from a 47-year-old patient with a history of heavy smoking was compatible with metastatic small cell carcinoma, and the second biopsy taken during decompression craniotomy 3 weeks later was compatible with WHO Grade IV glioblastoma. Using short tandem repeat (STR) analysis of the two specimens and nontumor-derived patient DNA, the authors found that the two specimens did not belong to the same individual. The authors conclude that allele imbalance or loss of heterozygosity detected by STR analysis is a reliable and valuable diagnostic tool for clarifying discrepancies in discordant pathology reports.


2021 ◽  
Vol 3 (01) ◽  
pp. 45-46
Author(s):  
Ali Niyaf ◽  
Kiran Niraula ◽  
Chandra Prakash Limbu ◽  
Arusha Ali Rasheed ◽  
Aminath Zauma

Hemostasis is one of the most essential measures in Neurological procedures. Surgicel (Oxidized cellulose) is one of the most frequently used hemostatic agent used worldwide during surgical procedures. We aim to present a case of radiological diagnostic dilemma of a ring enhancing brain lesion where brain abscess, intracranial hematoma and surgicelloma was identified as challenging differential diagnosis. In this paper, we present a case, where a complication occurred with the use of surgicel following craniectomy and evacuation of hematoma.


2019 ◽  
Vol 25 ◽  
pp. 143-144
Author(s):  
Muhammad Ansar ◽  
Joseph Dillon
Keyword(s):  

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