Comparison of Macular Thickness Measurements Using Swept-Source and Spectral-Domain Optical Coherence Tomography in Healthy and Diabetic Subjects

AbstractPurposeTo compare macular thicknesses measured using swept-source optical coherence tomography (SS-OCT) and spectral domain OCT (SD-OCT) in normal subjects, diabetics with diabetic retinopathy (DR) and diabetics without DR (NDR).MethodsWe analysed 510 normal eyes, 741 NDR eyes and 209 DR eyes. Mean macular thicknesses in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, central point thicknesses (CPT), and macular volume were measured by SS-OCT and SD-OCT. We assessed agreement between SS-OCT and SD-OCT measurements by intraclass correlation coefficients (ICC) and Bland-Altman plots, and established a conversion equation relating central subfield (CSF), CPT and macular volume between the two devices.ResultsMacular thickness measurements by SS-OCT were significantly thinner than those by SD-OCT. The mean CSF thickness in normal eyes measured by SD-OCT and SS-OCT were 226.6 ± 19.1 μm (male 236.1 ± 19.1 μm vs female 223.0 ± 17.9 μm, p < 0.0001) and 258.4 ± 19.8 μm. In all three groups, the agreement between SS-OCT and SD-OCT was excellent (all ICC ≥ 0.866). For CSF the conversion equation SD-OCT = 31.95 + 0.999 × SS-OCT was derived. Using the equation, with 99.6% and 97.6% of the predicted values for CSF fell within 10% of the actual measurements in DR and NDR eyes, respectively.ConclusionWe propose SS-OCT CSF thicknesses of 275 μm for males and 260 μm for females as the minimum criteria for macular edema in Chinese eyes. And SS-OCT measurements were significantly thinner than those of SD-OCT, we derived an equation to convert SS-OCT measurements to SD-OCT equivalents.

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Segmentation error and macular thickness measurements obtained with spectral-domain optical coherence tomography devices in neovascular age-related macular degeneration

Indian Journal of Ophthalmology ◽

10.4103/0301-4738.97075 ◽

2013 ◽

Vol 61 (5) ◽

pp. 213 ◽

Cited By ~ 11

Author(s):

Seung-Young Yu ◽

Jisang Han ◽

Moosang Kim ◽

HyungWoo Kwak ◽

SeungJun Lee

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Macular Thickness ◽

Age Related Macular Degeneration ◽

Spectral Domain ◽

Optical Coherence ◽

Segmentation Error ◽

Age Related ◽

Thickness Measurements

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Subfoveal choroidal thickness measurements in spectral-domain and swept-source optical coherence tomography devices

Oman Journal of Ophthalmology ◽

10.4103/ojo.ojo_69_2018 ◽

2018 ◽

Vol 11 (3) ◽

pp. 306

Author(s):

IsaacW Chay ◽

LouisW Lim ◽

KaiXiong Cheong ◽

ColinS Tan

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Swept Source ◽

Subfoveal Choroidal Thickness ◽

Thickness Measurements

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Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

PLoS ONE ◽

10.1371/journal.pone.0222850 ◽

2019 ◽

Vol 14 (10) ◽

pp. e0222850 ◽

Cited By ~ 2

Author(s):

Nora Denk ◽

Peter Maloca ◽

Guido Steiner ◽

Christian Freichel ◽

Simon Bassett ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Cynomolgus Monkeys ◽

Thickness Measurements ◽

Sd Oct

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Comparison of Choroidal Thickness Measurements between Spectral-domain Optical Coherence Tomography and Swept-source Optical Coherence Tomography in Children

10.21203/rs.3.rs-149964/v1 ◽

2021 ◽

Author(s):

Chun On Lee ◽

Xiujuan Zhang ◽

Shumin Tang ◽

Li Jia Chen ◽

Carol Cheung ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Correlation Coefficient ◽

Choroidal Thickness ◽

Relative Difference ◽

Spectral Domain ◽

Optical Coherence ◽

Normal Children ◽

Swept Source ◽

Thickness Measurements ◽

Sd Oct

Abstract PURPOSE: Choroidal thickness is associated with many ocular conditions, interchangeability among different generations of optical coherence tomography is therefore important for both research purpose and clinical application. Hence, we compared choroidal thickness measurements between spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomography (SS-OCT) in healthy pediatric eyes.METHODS: Children from the population–based Hong Kong Children Eye Study were recruited. Choroidal thickness was measured by both devices. Intra-class correlation coefficient (ICC) was used to compare the measurements.RESULTS: A total of 114 children with mean age of 7.38±0.82 years were included. The central foveal choroidal thickness (CFCT) measured by SD-OCT and SS-OCT was 273.24±54.29μm and 251.84±47.12μm respectively. Inter-device correlation coefficient was 0.840 (95%CI: 0.616-0.918). However, choroidal thickness obtained by SD-OCT was significantly thicker than that measured by SS-OCT with a mean difference of 21.40±33.13μm (P<0.001). Bland-Altman limit of agreement on the relative difference scale for SD-OCT/SS-OCT was 86.33μm. Validated conversion equation for translating SD-OCT CFCT measurement into SS-OCT was SS-OCT = 35.261 + 0.810 x SD-OCT. CONCLUSIONS: ICC shows an acceptable agreement between SD-OCT and SS-OCT, however, there was a significant inter-device difference of choroidal thickness measurements in normal children eyes. Therefore, the measurements are not interchangeable.

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