scholarly journals Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0222850 ◽  
Author(s):  
Nora Denk ◽  
Peter Maloca ◽  
Guido Steiner ◽  
Christian Freichel ◽  
Simon Bassett ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Cynomolgus Monkeys ◽  
Thickness Measurements ◽  
Sd Oct

scholarly journals Comparison of Macular Thickness Measurements Using Swept-Source and Spectral-Domain Optical Coherence Tomography in Healthy and Diabetic Subjects

2020 ◽  
Author(s):  
Kun Xiong ◽  
Wei Wang ◽  
Xia Gong ◽  
Wangting Li ◽  
Yuting Li ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Swept Source ◽  
Macular Volume ◽  
Conversion Equation ◽  
Thickness Measurements ◽  
Sd Oct

AbstractPurposeTo compare macular thicknesses measured using swept-source optical coherence tomography (SS-OCT) and spectral domain OCT (SD-OCT) in normal subjects, diabetics with diabetic retinopathy (DR) and diabetics without DR (NDR).MethodsWe analysed 510 normal eyes, 741 NDR eyes and 209 DR eyes. Mean macular thicknesses in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, central point thicknesses (CPT), and macular volume were measured by SS-OCT and SD-OCT. We assessed agreement between SS-OCT and SD-OCT measurements by intraclass correlation coefficients (ICC) and Bland-Altman plots, and established a conversion equation relating central subfield (CSF), CPT and macular volume between the two devices.ResultsMacular thickness measurements by SS-OCT were significantly thinner than those by SD-OCT. The mean CSF thickness in normal eyes measured by SD-OCT and SS-OCT were 226.6 ± 19.1 μm (male 236.1 ± 19.1 μm vs female 223.0 ± 17.9 μm, p < 0.0001) and 258.4 ± 19.8 μm. In all three groups, the agreement between SS-OCT and SD-OCT was excellent (all ICC ≥ 0.866). For CSF the conversion equation SD-OCT = 31.95 + 0.999 × SS-OCT was derived. Using the equation, with 99.6% and 97.6% of the predicted values for CSF fell within 10% of the actual measurements in DR and NDR eyes, respectively.ConclusionWe propose SS-OCT CSF thicknesses of 275 μm for males and 260 μm for females as the minimum criteria for macular edema in Chinese eyes. And SS-OCT measurements were significantly thinner than those of SD-OCT, we derived an equation to convert SS-OCT measurements to SD-OCT equivalents.

scholarly journals Comparison of Choroidal Thickness Measurements between Spectral-domain Optical Coherence Tomography and Swept-source Optical Coherence Tomography in Children

2021 ◽  
Author(s):  
Chun On Lee ◽  
Xiujuan Zhang ◽  
Shumin Tang ◽  
Li Jia Chen ◽  
Carol Cheung ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Correlation Coefficient ◽  
Choroidal Thickness ◽  
Relative Difference ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Normal Children ◽  
Swept Source ◽  
Thickness Measurements ◽  
Sd Oct

Abstract PURPOSE: Choroidal thickness is associated with many ocular conditions, interchangeability among different generations of optical coherence tomography is therefore important for both research purpose and clinical application. Hence, we compared choroidal thickness measurements between spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomography (SS-OCT) in healthy pediatric eyes.METHODS: Children from the population–based Hong Kong Children Eye Study were recruited. Choroidal thickness was measured by both devices. Intra-class correlation coefficient (ICC) was used to compare the measurements.RESULTS: A total of 114 children with mean age of 7.38±0.82 years were included. The central foveal choroidal thickness (CFCT) measured by SD-OCT and SS-OCT was 273.24±54.29μm and 251.84±47.12μm respectively. Inter-device correlation coefficient was 0.840 (95%CI: 0.616-0.918). However, choroidal thickness obtained by SD-OCT was significantly thicker than that measured by SS-OCT with a mean difference of 21.40±33.13μm (P<0.001). Bland-Altman limit of agreement on the relative difference scale for SD-OCT/SS-OCT was 86.33μm. Validated conversion equation for translating SD-OCT CFCT measurement into SS-OCT was SS-OCT = 35.261 + 0.810 x SD-OCT. CONCLUSIONS: ICC shows an acceptable agreement between SD-OCT and SS-OCT, however, there was a significant inter-device difference of choroidal thickness measurements in normal children eyes. Therefore, the measurements are not interchangeable.

Effects of Refractive Power on Macular Thickness Measurement Using Spectral-Domain Optical Coherence Tomography

2015 ◽  
Vol 234 (3) ◽  
pp. 172-176 ◽  
Author(s):  
Sung Bok Lee ◽  
Il Hwan Shin ◽  
Kyung Sup Shin ◽  
Young Joon Jo ◽  
Jung Yeul Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Contact Lenses ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Refractive Power ◽  
Sd Oct

Purpose: To investigate the effects of refractive power on macular thickness measurements by spectral-domain optical coherence tomography (SD-OCT). Subjects and Methods: For this prospective cohort study, a total of 50 eyes from 50 normal subjects with no systemic or ocular disease and no history of ocular surgery were studied from February 2014 to May 2014. We used soft contact lenses with a wide range of diopters to change the refractive power. The macular thickness of uncorrected eyes without contact lenses was measured by SD-OCT, and we compared the findings with the results of subsequent investigations in which macular thickness was measured in the presence of soft contact lenses of different diopters (-8, -4, 0, +4, and +8). We divided the patients into three groups according to the axial length (AL) and analyzed the effect of induced refraction change. The main outcome measure was macular thickness measured by OCT. Results: The average age of the subjects was 28.0 ± 3.4 years (mean ± SD), and included 17 eyes with normal AL, 18 eyes with mid-range AL, and 15 eyes with long AL. The central macular thickness was 254.5 ± 17.5 µm for eyes without contact lenses, which was not significantly different from the measurements in the presence of plano contact lenses (254.2 ± 18.1 µm). Even with soft contact lenses of four different diopters (-8, -4, +4, and +8), central macular thickness (254.4 ± 16.2, 253.7 ± 17.3, 257.3 ± 17.9, and 256.9 ± 17.9 µm, respectively) was not significantly different from that of naked eyes in each group. Conclusion: These results suggest that central macular thickness measured by SD-OCT is unaffected by refractive power.

Macular Thickness Measurements in Normal Eyes Using Spectral Domain Optical Coherence Tomography

2008 ◽  
Vol 39 (7) ◽  
pp. S43-S49 ◽  
Author(s):  
Giovanni Gregori ◽  
Robert W. Knighton ◽  
Carmen A. Puliafito ◽  
John E. Legarreta ◽  
Omar S. Punjabi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Thickness Measurements

Comparison of Macular Thickness Measurements between Time Domain and Spectral Domain Optical Coherence Tomography

2008 ◽  
Vol 49 (11) ◽  
pp. 4893 ◽  
Author(s):  
Christopher Kai-shun Leung ◽  
Carol Yim-lui Cheung ◽  
Robert N. Weinreb ◽  
Gary Lee ◽  
Dusheng Lin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Time Domain ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Thickness Measurements

scholarly journals Retinal thickness among normal myopic Filipinos using spectral domain optical coherence tomography

2020 ◽  
Vol 17 (2) ◽  
pp. 156-169
Author(s):  
Camille Elaine Zabala ◽  
Jubaida Mangondato-Aquino ◽  
Jose Ma. Martinez ◽  
John Mark De Leon
Keyword(s):  
Optical Coherence Tomography ◽  
High Myopia ◽  
Retinal Thickness ◽  
Spectral Domain ◽  
Pathologic Myopia ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Thickness Measurements ◽  
Sd Oct

Purpose: To determine mean macular and retinal nerve fiber layer (RNFL) thickness of myopic Filipinos using spectral domain optical coherence tomography (SD-OCT) and to evaluate influence of age, gender, and degree of myopia. Design: Observational clinic-based cohort. Methods: Participants were divided into two groups: low-moderate myopia [spherical equivalent (SE) -0.50 D to -6.00 D] and high-pathologic myopia (SE < -6.00 D and AL > 26.5 mm). Subgroup analyses between low myopia (refraction < -3.00 D or less) and moderate myopia (> -3.00 D to -6.00 D), and high myopia (> -6.00 D to -8.00 D) and pathologic myopia (more than -8.00 D) were done. Macular and RNFL thickness were measured by a SD-OCT and axial length (AL) with non-contact biometry. Results: Of 156 eyes, 88/156 (56%) had low-moderate myopia, 68/156 (44%) had high-pathologic myopia. There were 67/156 (43%) male and 89/156 (57%) female subjects. Mean central foveal subfield thickness measurements were 264 ± 24 μm for low myopia, 258 ± 17 μm for moderate myopia, 253 ± 25 μm for high myopia, and 218 ± 48 μm for pathologic myopia. Mean RNFL thickness measurements were 105.62 ± 3.89 μmfor low myopia, 97.6 ± 2.45 μm for moderate myopia, 85.9 ± 3.87 μm for high myopia, and 75.14 ± 3.89 μm for pathologic myopia. Average SE (p < 0.0001) decreased while AL (p < 0.0001) increased with more myopia. Myopia and age significantly affected macular and RNFL thickness parameters except for the following where only the degree of myopia was a significant factor: central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses. Conclusion: Retinal SD-OCT thickness measurements decreased with increasing level of myopia and age. Central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses may be more appropriate SD-OCT parameters among myopic Filipino patients to monitor for glaucoma since they may be less influenced by age.

scholarly journals Reproducibility of Choroidal Thickness Measurements in Hemodialysis Patients. A Spectral Domain Optical Coherence Tomography Study

2021 ◽  
Author(s):  
Özgür Eroğul ◽  
Mehmet Murat Uzel ◽  
Leyla Eryiğit Eroğul ◽  
Ayşe Güzin Taşlıpınar Uzel ◽  
Hamidu Hamısı Gobeka ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Correlation Coefficients ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Single Session ◽  
Intra Class Correlation ◽  
Coefficients Of Variation ◽  
Thickness Measurements ◽  
Sd Oct

Abstract PurposeTo investigate the effects of hemodialysis (HD) on the reproducibility of subfoveal choroidal thickness (SFCT) as measured by spectral domain-optical coherence tomography (SD-OCT)MethodsIn this study, 26 HD (26 eyes) patients had their pre- and post-HD SFCT measured, and the results were compared for reproducibility. Following a thorough ophthalmic examination, SD-OCT was performed three times in a row during a single session. The same physician measured SFCT after automatically identifying choroid with a software caliper. The reproducibility parameters, including intra-class correlation coefficients (ICCs), coefficients of variation (COV), and test-retest variability (TRTV) were then calculated.ResultsMales made up 53.85% of the 26 HD patients. There was a significant IOP difference between pre-HD (16.42±3.14 mmHg) and post-HD (14.21±2.78 mmHg) (P<0.001). SFCT decreased significantly from pre-HD 243.50±10.23 μm to post-HD 234.29±9.41 μm (P<0.001). ICC value increased significantly after HD, rising from 0.948 to 0.989 (P<0.001, for all). Pre- and post-HD COV values were 1.6% and 0.65%, respectively. Also, pre- and post-HD TRTV values were 7.864±1.996 μm and 3.074±1.536 μm, respectively.ConclusionThe reproducibility of SFCT as measured by OCT was lower during pre-HD compared to post-HD. Post-HD SD-OCT assessment appears to improve the reliability of clinical outcomes in the diagnosis and monitoring of HD patients.

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