scholarly journals Comparison of Macular Thickness Measurements Using Swept-Source and Spectral-Domain Optical Coherence Tomography in Healthy and Diabetic Subjects

2020 ◽  
Author(s):  
Kun Xiong ◽  
Wei Wang ◽  
Xia Gong ◽  
Wangting Li ◽  
Yuting Li ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Swept Source ◽  
Macular Volume ◽  
Conversion Equation ◽  
Thickness Measurements ◽  
Sd Oct

AbstractPurposeTo compare macular thicknesses measured using swept-source optical coherence tomography (SS-OCT) and spectral domain OCT (SD-OCT) in normal subjects, diabetics with diabetic retinopathy (DR) and diabetics without DR (NDR).MethodsWe analysed 510 normal eyes, 741 NDR eyes and 209 DR eyes. Mean macular thicknesses in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, central point thicknesses (CPT), and macular volume were measured by SS-OCT and SD-OCT. We assessed agreement between SS-OCT and SD-OCT measurements by intraclass correlation coefficients (ICC) and Bland-Altman plots, and established a conversion equation relating central subfield (CSF), CPT and macular volume between the two devices.ResultsMacular thickness measurements by SS-OCT were significantly thinner than those by SD-OCT. The mean CSF thickness in normal eyes measured by SD-OCT and SS-OCT were 226.6 ± 19.1 μm (male 236.1 ± 19.1 μm vs female 223.0 ± 17.9 μm, p < 0.0001) and 258.4 ± 19.8 μm. In all three groups, the agreement between SS-OCT and SD-OCT was excellent (all ICC ≥ 0.866). For CSF the conversion equation SD-OCT = 31.95 + 0.999 × SS-OCT was derived. Using the equation, with 99.6% and 97.6% of the predicted values for CSF fell within 10% of the actual measurements in DR and NDR eyes, respectively.ConclusionWe propose SS-OCT CSF thicknesses of 275 μm for males and 260 μm for females as the minimum criteria for macular edema in Chinese eyes. And SS-OCT measurements were significantly thinner than those of SD-OCT, we derived an equation to convert SS-OCT measurements to SD-OCT equivalents.

scholarly journals Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0222850 ◽  
Author(s):  
Nora Denk ◽  
Peter Maloca ◽  
Guido Steiner ◽  
Christian Freichel ◽  
Simon Bassett ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Cynomolgus Monkeys ◽  
Thickness Measurements ◽  
Sd Oct

scholarly journals Comparison of Choroidal Thickness Measurements between Spectral-domain Optical Coherence Tomography and Swept-source Optical Coherence Tomography in Children

2021 ◽  
Author(s):  
Chun On Lee ◽  
Xiujuan Zhang ◽  
Shumin Tang ◽  
Li Jia Chen ◽  
Carol Cheung ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Correlation Coefficient ◽  
Choroidal Thickness ◽  
Relative Difference ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Normal Children ◽  
Swept Source ◽  
Thickness Measurements ◽  
Sd Oct

Abstract PURPOSE: Choroidal thickness is associated with many ocular conditions, interchangeability among different generations of optical coherence tomography is therefore important for both research purpose and clinical application. Hence, we compared choroidal thickness measurements between spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomography (SS-OCT) in healthy pediatric eyes.METHODS: Children from the population–based Hong Kong Children Eye Study were recruited. Choroidal thickness was measured by both devices. Intra-class correlation coefficient (ICC) was used to compare the measurements.RESULTS: A total of 114 children with mean age of 7.38±0.82 years were included. The central foveal choroidal thickness (CFCT) measured by SD-OCT and SS-OCT was 273.24±54.29μm and 251.84±47.12μm respectively. Inter-device correlation coefficient was 0.840 (95%CI: 0.616-0.918). However, choroidal thickness obtained by SD-OCT was significantly thicker than that measured by SS-OCT with a mean difference of 21.40±33.13μm (P<0.001). Bland-Altman limit of agreement on the relative difference scale for SD-OCT/SS-OCT was 86.33μm. Validated conversion equation for translating SD-OCT CFCT measurement into SS-OCT was SS-OCT = 35.261 + 0.810 x SD-OCT. CONCLUSIONS: ICC shows an acceptable agreement between SD-OCT and SS-OCT, however, there was a significant inter-device difference of choroidal thickness measurements in normal children eyes. Therefore, the measurements are not interchangeable.

scholarly journals Corneal and Epithelial Thickness Mapping: Comparison of Swept-Source- and Spectral-Domain-Optical Coherence Tomography

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Cristina Georgeon ◽  
Ilanite Marciano ◽  
Roxane Cuyaubère ◽  
Otman Sandali ◽  
Nacim Bouheraoua ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Spectral Domain ◽  
Lamellar Keratoplasty ◽  
Optical Coherence ◽  
Swept Source ◽  
Epithelial Thickness ◽  
Spectral Domain Oct ◽  
Anterior Lamellar Keratoplasty ◽  
Sd Oct

Objective. To compare the results and repeatability of the corneal thickness (CT) and epithelial thickness (ET) maps provided by Swept-Source-Optical Coherence Tomography with those of Spectral-Domain-OCT in normal eyes. Methods. 30 normal eyes of 30 patients were assessed by 3 trained operators with SS-OCT and SD-OCT. Results. The central and minimum ET obtained with both devices were correlated: central ET, r = 0.86, p < 0.05 ; minimum ET, r = 0.72, p < 0.05 . Compared with SD-OCT, SS-OCT tended to underestimate these figures by 1.4 and 1.9 μm on average. The central and minimum CT obtained with both devices were strongly correlated: central CT, r = 0.994, p < 0.05 ; minimum CT, r = 0.995, p < 0.05 . SS-OCT tended to overestimate these figures by 11 and 14 μm on average. Repeatability was good for both devices with a mean coefficient of variation of measurements <6% for ET and <2% for CT. Interoperator variability (standard deviation and COV) was significantly higher for SS-OCT than for SD-OCT for all local epithelial thicknesses and significantly lower for the central CT and several local corneal thicknesses, whereas no significant differences between both technologies were found for the central and minimum ET and the minimum CT. Conclusion. SS-OCT and SD-OCT provide reproducible measurements of CT and ET in normal corneas with a strong correlation between both technologies. However, both technologies are not interchangeable when the main thickness parameters (i.e., central and minimum CT and minimum ET) are used for diagnosing early keratoconus or calculating the expected residual stromal bed thickness before corneal refractive surgery or anterior lamellar keratoplasty.

A Study of Retinal Nerve Fiber Layer Thickness by using Spectral Domain Optical Coherence Tomography in Older Adults with Diabetes Mellitus

2019 ◽  
Vol 15 (1) ◽  
pp. 17-21
Author(s):  
Devendra Sharma ◽  
Arvind Chauhan ◽  
Avisha Mathur
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness

Introduction: Peripapillary retinal nerve fiber layer (RNFL) thinning occurs in the diabetic patients earlier than the detectable diabetic retinopathy. We conducted this study to evaluate the RNFL thickness and macular thickness in elderly diabetic patients using optical coherence tomography in comparison to healthy controls. Material and methods: One fifty study participants were divided in 3 groups (50 each): normal subjects, patients with diabetes with no detectable diabetic retinopathy (NDR) and patients with diabetic retinopathy (DR) of differing severity. The RNFL thickness and macular thickness was measured using spectral-domain optical coherence tomography (SD OCT). Results: The RNFL thickness around the optic disc differed significantly among all the 3 groups and tended to become thinner as the patient develops DR in elderly subjects. The mean, superior-temporal and upper nasal peripapillary RNFL thickness differed among all the 3 groups. We observed that, mean superior, temporal, inferior and nasal RNFL tended to be thinner as the patient develops DR. Conclusion: The RNFL thickness, macular thickness and ganglion cell complex thinning differed significantly between the healthy group and diabetic group without clinical DR. The RNFL thinning (measured by Spectral-domain OCT) is an early neurodegenerative ocular change in diabetic patients even before onset of diabetic retinopathy.

Effects of Refractive Power on Macular Thickness Measurement Using Spectral-Domain Optical Coherence Tomography

2015 ◽  
Vol 234 (3) ◽  
pp. 172-176 ◽  
Author(s):  
Sung Bok Lee ◽  
Il Hwan Shin ◽  
Kyung Sup Shin ◽  
Young Joon Jo ◽  
Jung Yeul Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Contact Lenses ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Refractive Power ◽  
Sd Oct

Purpose: To investigate the effects of refractive power on macular thickness measurements by spectral-domain optical coherence tomography (SD-OCT). Subjects and Methods: For this prospective cohort study, a total of 50 eyes from 50 normal subjects with no systemic or ocular disease and no history of ocular surgery were studied from February 2014 to May 2014. We used soft contact lenses with a wide range of diopters to change the refractive power. The macular thickness of uncorrected eyes without contact lenses was measured by SD-OCT, and we compared the findings with the results of subsequent investigations in which macular thickness was measured in the presence of soft contact lenses of different diopters (-8, -4, 0, +4, and +8). We divided the patients into three groups according to the axial length (AL) and analyzed the effect of induced refraction change. The main outcome measure was macular thickness measured by OCT. Results: The average age of the subjects was 28.0 ± 3.4 years (mean ± SD), and included 17 eyes with normal AL, 18 eyes with mid-range AL, and 15 eyes with long AL. The central macular thickness was 254.5 ± 17.5 µm for eyes without contact lenses, which was not significantly different from the measurements in the presence of plano contact lenses (254.2 ± 18.1 µm). Even with soft contact lenses of four different diopters (-8, -4, +4, and +8), central macular thickness (254.4 ± 16.2, 253.7 ± 17.3, 257.3 ± 17.9, and 256.9 ± 17.9 µm, respectively) was not significantly different from that of naked eyes in each group. Conclusion: These results suggest that central macular thickness measured by SD-OCT is unaffected by refractive power.

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