Association between Topographic Features of the Retinal Nerve Fiber Bundle and Good Visual Acuity in Patients with Glaucoma

Purpose. To describe different clinical characteristics and prognosis of optic neuritis (ON) in male patients with seropositive aquaporin-4 antibody (AQP4-Ab) or myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China. Method. Males with ON were recruited from the Neuro-ophthalmology Department of the Chinese People’s Liberation Army, General Hospital from January 2016 to February 2018. They were assigned to two groups based on antibodies status: MOG-Ab-seropositive ON (MOG-ON) and aquaporin-4 Ab-seropositive ON (AQP4-ON). Results. Seventy-six male patients were assessed, including 44 MOG-ON (57.9%) and 32 AQP4-ON (42.1%). The MOG-ON patients were significantly younger at onset compared to the AQP4-ON group (p<0.001). Frequencies of optic disc swelling, presence of abnormal autoimmune antibodies, and elevated levels of CSF IgG were significantly higher in the AQP4-ON group than the MOG-ON group (p=0.040, p=0.016, and p=0.10, respectively). At the final visit, 85.3% of MOG-ON eyes had increased visual acuity (≥0.5) compared to 35.1% of AQP4-ON eyes (p<0.001). The ratio of this steroid-dependent condition is higher in MOG-ON patients than the AQP4-ON group (p<0.001). The ratio of conversion to NMO is higher in the AQP4-ON group than the MOG-ON group, with more AQP4-ON patients developing NMO by the follow-up (p=0.012). MOG-ON patients had thicker average peripapillary retinal nerve fiber layers and macular ganglion cell-inner plexiform than AQP4-ON patients (p=0.008 and p=0.012, respectively). Orbital MRI revealed more AQP4-ON patients had chiasmal involvement than MOG-ON patients (p<0.001). Conclusion. Male MOG-ON patients had different clinical features including earlier age of onset, higher optic disc swelling ratio, better visual acuity recovery, thicker peripapillary retinal nerve fiber and macular ganglion cell-inner plexiform layers, and less chiasmal involvement than male AQP4-ON patients. Serum antibody may be a potential biomarker for determining visual prognosis in male ON.

Download Full-text

Ocular imaging findings of bilateral optic disc pit in a child

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v5i2.8739 ◽

2013 ◽

Vol 5 (2) ◽

pp. 258-261 ◽

Cited By ~ 1

Author(s):

Abdullah Ozkaya ◽

Z Alkin ◽

AT Taylan ◽

A Demirok

Keyword(s):

Visual Acuity ◽

Optic Nerve ◽

Nerve Fiber ◽

Optic Disc ◽

Anterior Segment ◽

Rare Condition ◽

Optic Disc Pit ◽

Fiber Layer ◽

Retinal Nerve Fiber

Background: To report a rare condition of bilateral optic disc pit in a child. Case description: A ten-year-old female was admitted with a complaint of headache. Visual acuity was 20/20 in both eyes (OU). Anterior segment examination was normal in OU. Fundus examination revealed optic disc pit (ODP) located temporally with a diameter of 1/5 disc diameter in OU. Intraocular pressure was within normal limits in both eyes. Macular optical coherence tomography (OCT) showed a loss of retinal tissue at the site corresponding to the ODP in both eyes. Retinal nerve fiber OCT revealed decreased RNFL thickness at the temporal side of the optic nerve, corresponding to the ODP in both eyes. The patient and patient’s parents were informed about the disease and called for follow-up examinations every 6 months. In addition, the family was informed about optic pit maculopathy (OPM) and, they were told to return immediately if the patient ever complained of decreased vision in either of her eyes. After a follow-up period of 12 months, visual acuity remained stable, and no complications secondary to ODP were detected. Conclusion: Optic disc pit is diagnosed incidentally unless it is complicated with OPM. The retinal nerve fiber layer thickness is decreased at the side of the optic nerve corresponding to the ODP. Nepal J Ophthalmol 2013; 5(10): 258-261 DOI: http://dx.doi.org/10.3126/nepjoph.v5i2.8739

Download Full-text

Novel Technique for Quantifying Retinal Nerve Fiber Bundle Abnormality in the Temporal Raphe

Optometry and Vision Science ◽

10.1097/opx.0000000000001202 ◽

2018 ◽

Vol 95 (4) ◽

pp. 309-317 ◽

Cited By ~ 8

Author(s):

Bright S. Ashimatey ◽

Brett J. King ◽

Victor E. Malinovsky ◽

William H. Swanson

Keyword(s):

Nerve Fiber ◽

Fiber Bundle ◽

Novel Technique ◽

Retinal Nerve Fiber

Download Full-text

A mathematical model for describing the retinal nerve fiber bundle trajectories in the human eye: Average course, variability, and influence of refraction, optic disc size and optic disc position

Experimental Eye Research ◽

10.1016/j.exer.2012.10.008 ◽

2012 ◽

Vol 105 ◽

pp. 70-78 ◽

Cited By ~ 31

Author(s):

Nomdo M. Jansonius ◽

Julia Schiefer ◽

Jukka Nevalainen ◽

Jens Paetzold ◽

Ulrich Schiefer

Keyword(s):

Mathematical Model ◽

Nerve Fiber ◽

Optic Disc ◽

Fiber Bundle ◽

Human Eye ◽

Optic Disc Size ◽

Disc Position ◽

Disc Size ◽

Retinal Nerve Fiber

Download Full-text

Comparison of Macular And Retinal Nerve Fiber Layer Thickness In Amblyopic And Fellow Eyes

Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy ◽

10.5222/bmj.2021.84803 ◽

2021 ◽

Author(s):

Ceren Gürez

Keyword(s):

Visual Acuity ◽

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

The Mean ◽

Fellow Eyes ◽

Retinal Nerve Fiber

Purpose: The purpose of this study is to investigate the relationship between macular and peripapillary retinal nerve fiber layer thickness and amblyopia. Methods: A total of 56 pediatric patients with hyperopic anisometropic amblyopia were evaluated in this study. As the control group, we used the patients’ fellow eyes. A comprehensive eye examination was performed, including best-corrected visual acuity with Snellen charts (converted to logMAR for analysis), slit-lamp examination, fundus examination, cover and, cover-uncover testing, and ocular motility testing. The macular thickness, retinal nerve fiber layer thickness, axial length and optic disc area of both eyes were measured. Results: The mean age was 7.25±1.89 years. For the amblyopic and fellow eyes, the mean best-corrected visual acuity was 0.33± 0.20 logMAR and 0.0± 0.0 logMAR, respectively. Macular center thicknesses were 225,55±18,86 µm and 215,7±12,96 µm in amblyopic and fellow eyes, respectively. Macular 6mm ring thicknesses were 281,32±33,51 µm and 256,07±28,91 µm in amblyopic and fellow eyes, respectively. RNFLT were 108,39±11,59 µm and 104,61±8,43 µm in amblyopic and fellow eyes, respectively There was a statistically significant difference in the macular center thickness, in macular 6-mm ring area thickness and in RNFLT (p<0.05). There was a positive correlation between visual acuity of amblyopic eyes and macular thickness and RNFLT. Conclusions: This study explored objectively measured retinal changes in amblyopia and found a slightly thicker central macular region and 6-mm ring area thicknesses and RNFLT in amblyopic compared with normal eyes.

Download Full-text