Abscesses of the breast: US-guided serial percutaneous aspiration and local antibiotic therapy after unsuccessful systemic antibiotic therapy

2001 ◽  
Vol 42 (2) ◽  
pp. 161-165 ◽  
Author(s):  
A. Imperiale ◽  
F. Zandrino ◽  
M. Calabrese ◽  
G. Parodi ◽  
T. Massa
Keyword(s):  
Antibiotic Therapy ◽  
Percutaneous Aspiration ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

scholarly journals Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Maria Dudareva ◽  
Michelle Kümin ◽  
Werner Vach ◽  
Klaus Kaier ◽  
Jamie Ferguson ◽  
...  
Keyword(s):  
Side Effects ◽  
Antibiotic Therapy ◽  
Treatment Failure ◽  
Open Label ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Randomised Controlled ◽  
Systemic Antibiotics ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

Abstract Background Orthopaedic infections, such as osteomyelitis, diabetic foot infection and prosthetic joint infection, are most commonly treated by a combination of surgical debridement and a prolonged course of systemic antibiotics, usually for at least 4–6 weeks. Use of local antibiotics, implanted directly into the site of infection at the time of surgery, may improve antibiotic delivery and allow us to shorten the duration of systemic antibiotic therapy, thereby limiting the frequency of side effects, cost and selection pressure for antimicrobial resistance. Methods SOLARIO is a multicentre open-label randomised controlled non-inferiority trial comparing short and long systemic antibiotic therapy alongside local antibiotic therapy. Adult patients with orthopaedic infection, who have given informed consent, will be eligible to participate in the study provided that no micro-organisms identified from deep tissue samples are resistant to locally implanted antibiotics. Participants will be randomised in a 1:1 ratio to receive either a short course (≤ 7 days) or currently recommended long course (≥ 4 weeks) of systemic antibiotics. The primary outcome will be treatment failure by 12 months after surgery, as ascertained by an independent Endpoint Committee blinded to treatment allocation. An absolute non-inferiority margin of 10% will be used for both per-protocol and intention-to-treat populations. Secondary outcomes will include probable and definite treatment failure, serious adverse events, treatment side effects, quality of life scores and cost analysis. Discussion This study aims to assess a treatment strategy that may enable the reduction of systemic antibiotic use for patients with orthopaedic infection. If this strategy is non-inferior, this will be to the advantage of patients and contribute to antimicrobial stewardship. Trial registration Clinicaltrials.gov, NCT03806166. Registered on 11 November 2019.

scholarly journals Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a Randomised Controlled Open-Label Non-Inferiority Trial of Duration of Systemic Antibiotics in Adults with Orthopaedic Infection Treated Operatively with Local Antibiotic Therapy

2019 ◽  
Author(s):  
Maria Dudareva ◽  
Michelle Kümin ◽  
Werner Vach ◽  
Klaus Kaier ◽  
Jamie Ferguson ◽  
...  
Keyword(s):  
Side Effects ◽  
Antibiotic Therapy ◽  
Treatment Failure ◽  
Open Label ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Randomised Controlled ◽  
Systemic Antibiotics ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

Abstract Background Orthopaedic infections such as osteomyelitis, diabetic foot infection and prosthetic joint infection, are most commonly treated by a combination of surgical debridement and a prolonged course of systemic antibiotics, usually for at least 4 -6 weeks. Use of local antibiotics, implanted directly into the site of infection at the time of surgery, may improve antibiotic delivery and allow us to shorten the duration of systemic antibiotic therapy, thereby limiting the frequency of side effects, cost and selection pressure for antimicrobial resistance. Methods SOLARIO is a multi-centre open label randomised controlled non-inferiority trial comparing short and long systemic antibiotic therapy alongside local antibiotic therapy. Adult patients with orthopaedic infection, who have given informed consent, will be eligible to participate in the study provided that no micro-organisms identified from deep tissue samples are resistant to locally-implanted antibiotics. Participants will be randomised in a 1:1 ratio to receive either a short course (≤ 7 days) or currently recommended long course (≥ 4 weeks) of systemic antibiotics. The primary outcome will be treatment failure by 12 months following surgery, as ascertained by an independent Endpoint Committee blinded to treatment allocation. An absolute non-inferiority margin of 10% will be used for both per-protocol and intention-to-treat populations. Secondary outcomes will include probable and definite treatment failure, serious adverse events, treatment side-effects, quality of life scores and cost analysis. Discussion This study aims to assess a treatment strategy that may enable the reduction of systemic antibiotic use for patients with orthopaedic infection. If effective, this will be to the advantage of patients and contribute to antimicrobial stewardship.

scholarly journals Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a Randomised Controlled Open-Label Non-Inferiority Trial of Duration of Systemic Antibiotics in Adults with Orthopaedic Infection Treated Operatively with Local Antibiotic Therapy

2019 ◽  
Author(s):  
Maria Dudareva ◽  
Michelle Kümin ◽  
Werner Vach ◽  
Klaus Kaier ◽  
Jamie Ferguson ◽  
...  
Keyword(s):  
Side Effects ◽  
Antibiotic Therapy ◽  
Treatment Failure ◽  
Open Label ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Randomised Controlled ◽  
Systemic Antibiotics ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

Abstract Background Orthopaedic infections such as osteomyelitis, diabetic foot infection and prosthetic joint infection, are most commonly treated by a combination of surgical debridement and a prolonged course of systemic antibiotics, usually for at least 4 -6 weeks. Use of local antibiotics, implanted directly into the site of infection at the time of surgery, may improve antibiotic delivery and allow us to shorten the duration of systemic antibiotic therapy, thereby limiting the frequency of side effects, cost and selection pressure for antimicrobial resistance. Methods SOLARIO is a multi-centre open label randomised controlled non-inferiority trial comparing short and long systemic antibiotic therapy alongside local antibiotic therapy. Adult patients with orthopaedic infection, who have given informed consent, will be eligible to participate in the study provided that no micro-organisms identified from deep tissue samples are resistant to locally-implanted antibiotics. Participants will be randomised in a 1:1 ratio to receive either a short course (≤ 7 days) or currently recommended long course (≥ 4 weeks) of systemic antibiotics. The primary outcome will be treatment failure by 12 months following surgery, as ascertained by an independent Endpoint Committee blinded to treatment allocation. An absolute non-inferiority margin of 10% will be used for both per-protocol and intention-to-treat populations. Secondary outcomes will include probable and definite treatment failure, serious adverse events, treatment side-effects, quality of life scores and cost analysis. Discussion This study aims to assess a treatment strategy that may enable the reduction of systemic antibiotic use for patients with orthopaedic infection. If effective, this will be to the advantage of patients and contribute to antimicrobial stewardship.

Development and application of antibiotic-loaded bone cement beads

1990 ◽  
Vol 80 (7) ◽  
pp. 354-359 ◽  
Author(s):  
DE Stabile ◽  
AM Jacobs
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Bone Cement ◽  
Clinical Judgment ◽  
Soft Tissue Infections ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Local Antibiotic ◽  
Vascular Status ◽  
Causes Of Failure

The authors presented an overview of the development of antibiotic-loaded bone cement beads and their indications for usage, method of application, advantages, disadvantages, and causes of failure. This method of treatment for bone and soft tissue infections of the foot is not a panacea and should be used only in selected cases. The vascular status and the physiologic ability of the patient to heal a peripheral wound or infection are the basis for the success of this method of therapy. European literature makes little mention of adjunctive systemic antibiotic therapy with local antibiotic-loaded bone cement bead use. It is the authors' opinion that clinical judgment should be used to determine the necessity for such therapy.

Delayed tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline

2015 ◽  
Vol 31 (6) ◽  
pp. 448-456 ◽  
Author(s):  
Weglis Dyanne de Souza Gomes ◽  
Cristina Antoniali Silva ◽  
Moriel Evangelista Melo ◽  
Vanessa Ferreira da Silva ◽  
Melyna Marques de Almeida ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Systemic Antibiotic ◽  
Tooth Replantation ◽  
Systemic Antibiotic Therapy

Systemic antibiotic therapy in periodontics

1996 ◽  
Vol 10 (1) ◽  
pp. 45-78 ◽  
Author(s):  
Arie Jan Van Winkelhoff ◽  
Thomas E. Rams ◽  
Jørgen Slots
Keyword(s):  
Antibiotic Therapy ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy

Timing Affects the Clinical Outcome of Adjunctive Systemic Antibiotic Therapy for Generalized Aggressive Periodontitis

2007 ◽  
Vol 78 (7) ◽  
pp. 1201-1208 ◽  
Author(s):  
Doğan Kaner ◽  
Claudia Christan ◽  
Thomas Dietrich ◽  
Jean-Pierre Bernimoulin ◽  
Bernd-Michael Kleber ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Antibiotic Therapy ◽  
Aggressive Periodontitis ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy

Search for algorithms for treatment of non-specific septic spondylodiscitis

2020 ◽  
pp. 65-72
Author(s):  
V. N. Obolensky ◽  
A. V. Sytnik
Keyword(s):  
Antibiotic Therapy ◽  
Negative Pressure ◽  
Spinal Column ◽  
Treatment Results ◽  
Pressure Method ◽  
Personalized Approach ◽  
Staged Treatment ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

The treatment results of 30 patients with non-specific purulent diseases of the spine were analyzed using various methods — primary or secondary stabilization of the spinal column, local negative pressure method, prolonged local antibiotic therapy method and various implants. The results were rated as «excellent» in 16 patients, «good» in 7 people, «satisfactory» in 4 cases (relapses) and 3 patients died. The results obtained indicate the need for a personalized approach to treatment tactics, the feasibility of staged treatment and the use of additional methods.

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