Basic approaches of some of the reliability models available for analyzing the effect of operating conditions (or covariates) on the lifetime of a system are shortly discussed, and a general guideline for how to select an appropriate model for a given data set is provided. Some of the models have theoretical and computational difficulties which make them difficult to apply. Models that appear to be suitable for practical applications can broadly be classified as the class of proportional hazards models and the class of accelerated failure time models. In the class of proportional hazards models, e.g. the proportional hazards model and the proportional odds model, the effect of the covariates is assumed to act multiplicatively on the hazard rate or its transformations. In the class of accelerated failure time models, e.g. the parametric regression models, the effect of the covariates is assumed to act multiplicatively on the failure time or its transformations. Models from the proportional hazards family appear to be the better ones for analyzing the effect of the covariates due to the method used for estimating the parameters of these models.