Robust Bayesian estimator in a normal model with uncertain hierarchical priors

Author(s):  
Guikai Hu ◽  
Xinhai Xiao
2004 ◽  
Vol 2004 (8) ◽  
pp. 421-429 ◽  
Author(s):  
Souad Assoudou ◽  
Belkheir Essebbar

This note is concerned with Bayesian estimation of the transition probabilities of a binary Markov chain observed from heterogeneous individuals. The model is founded on the Jeffreys' prior which allows for transition probabilities to be correlated. The Bayesian estimator is approximated by means of Monte Carlo Markov chain (MCMC) techniques. The performance of the Bayesian estimates is illustrated by analyzing a small simulated data set.


Blood ◽  
2021 ◽  
Author(s):  
Anne-Fleur Zwagemaker ◽  
Samantha C Gouw ◽  
Julie J Jansen ◽  
Caroline Vuong ◽  
Michiel Coppens ◽  
...  

Intracranial hemorrhage (ICH) is a severe complication that is relatively common among hemophilia patients. This systematic review aimed to obtain more precise estimates of ICH incidence and mortality in hemophilia, which may be important for patients, caregivers, researchers and health policy-makers. PubMed and EMBASE were systematically searched using terms related to "hemophilia" and "intracranial hemorrhage" or "mortality". Studies that allowed calculation of ICH incidence or mortality rates in a hemophilia population of at least 50 patients were included. We summarized evidence on ICH incidence and calculated pooled ICH incidence and mortality in three age groups: (1) persons of all ages with hemophilia, (2) children and young adults below 25 years of age with hemophilia and (3) neonates with hemophilia. Incidence and mortality were pooled with a Poisson-Normal model or a Binomial-Normal model. We included 45 studies that represented 54 470 patients, 809 151 person-years and 5326 live births of hemophilia patients. In persons of all ages, the pooled ICH incidence and mortality rates were 2.3 (95% CI 1.2-4.8) and 0.8 (95% CI 0.5-1.2) per 1000 person-years, respectively. In children and young adults, the pooled ICH incidence and mortality rates were 7.4 (95% CI 4.9-11.1) and 0.5 (95% CI 0.3-0.9) per 1000 person-years, respectively. In neonates, the pooled cumulative ICH incidence was 2.1% (95% CI 1.5-2.8) per 100 live births. ICH was classified as spontaneous in 35-58% of cases. Our findings suggest that ICH is an important problem in hemophilia that occurs among all ages, requiring adequate preventive strategies.


2012 ◽  
Vol 2 (1) ◽  
pp. 7 ◽  
Author(s):  
Andrzej Kijko

This work is focused on the Bayesian procedure for the estimation of the regional maximum possible earthquake magnitude <em>m</em><sub>max</sub>. The paper briefly discusses the currently used Bayesian procedure for m<sub>max</sub>, as developed by Cornell, and a statistically justifiable alternative approach is suggested. The fundamental problem in the application of the current Bayesian formalism for <em>m</em><sub>max</sub> estimation is that one of the components of the posterior distribution is the sample likelihood function, for which the range of observations (earthquake magnitudes) depends on the unknown parameter <em>m</em><sub>max</sub>. This dependence violates the property of regularity of the maximum likelihood function. The resulting likelihood function, therefore, reaches its maximum at the maximum observed earthquake magnitude <em>m</em><sup>obs</sup><sub>max</sub> and not at the required maximum <em>possible</em> magnitude <em>m</em><sub>max</sub>. Since the sample likelihood function is a key component of the posterior distribution, the posterior estimate of <em>m^</em><sub>max</sub> is biased. The degree of the bias and its sign depend on the applied Bayesian estimator, the quantity of information provided by the prior distribution, and the sample likelihood function. It has been shown that if the maximum posterior estimate is used, the bias is negative and the resulting underestimation of <em>m</em><sub>max</sub> can be as big as 0.5 units of magnitude. This study explores only the maximum posterior estimate of <em>m</em><sub>max</sub>, which is conceptionally close to the classic maximum likelihood estimation. However, conclusions regarding the shortfall of the current Bayesian procedure are applicable to all Bayesian estimators, <em>e.g.</em> posterior mean and posterior median. A simple, <em>ad hoc</em> solution of this non-regular maximum likelihood problem is also presented.


2012 ◽  
Vol 7 (1) ◽  
pp. 3-25 ◽  
Author(s):  
Michael Merz ◽  
Mario V. Wüthrich ◽  
Enkelejd Hashorva

AbstractA central issue in claims reserving is the modelling of appropriate dependence structures. Most classical models cannot cope with this task. We define a multivariate log-normal model that allows to model both, dependence between different sub-portfolios and dependence within sub-portfolios such as claims inflation. In this model we derive closed form solutions for claims reserves and the corresponding prediction uncertainty.


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