A sensitive and high-throughput LC-ESI-MS/MS method to detect budesonide in human plasma: application to an evaluation of pharmacokinetics of budesonide intranasal formulations with and without charcoal-block in healthy volunteers

2021 ◽  
Vol 47 (2) ◽  
pp. 329-336
Author(s):  
Xin Li ◽  
Huan Tong ◽  
Bing Xu ◽  
Yang Deng ◽  
Yuan Li ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Human Plasma ◽  
High Throughput ◽  
Esi Ms

LC–MS/MS method for the quantification of SUVN-G3031, a novel H3 receptor inverse agonist for narcolepsy treatment

Bioanalysis ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 533-544 ◽  
Author(s):  
Ramakrishna Nirogi ◽  
Devender Reddy Ajjala ◽  
Naga Surya Prakash Padala ◽  
Ilayaraja Kalaikadhiban ◽  
Lakshmi Prasanna Rayapati ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Human Plasma ◽  
Human Study ◽  
Inverse Agonist ◽  
Clinical Development ◽  
Protein Precipitation ◽  
Esi Ms ◽  
H3 Receptor ◽  
Receptor Inverse Agonist

Background: A LC–MS/MS method was validated for the quantification of SUVN-G3031, a novel H3 receptor inverse agonist in clinical development for the treatment of patients with narcolepsy, with and without cataplexy. Methodology: SUVN-G3031 was extracted from plasma following acetonitrile protein precipitation, separated by Ultra HPLC and quantified using positive ESI–MS/MS. Results: The method was linear across the range of 0.1–100 ng ml-1 in plasma. Results for intra and inter-day accuracy were from 99.8 to 104% and precision (%CV) was ≤10.6%. Conclusion: The method was applied to a first-in-human study in healthy volunteers. The method is precise, accurate and highly selective for the quantification of SUVN-G3031 in human plasma.

Validation of a HPLC-ESI MS/MS method for the determination of clonidine in human plasma and its application in a bioequivalence study in Chinese healthy volunteers

2015 ◽  
Vol 29 (10) ◽  
pp. 1506-1513 ◽  
Author(s):  
Jialang Zhuang ◽  
Jiangying Chen ◽  
Xueding Wang ◽  
Yin Pang ◽  
Huichang Bi ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Human Plasma ◽  
Bioequivalence Study ◽  
Esi Ms

scholarly journals Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples

2021 ◽  
Vol 2 (3) ◽  
pp. 100606
Author(s):  
Giuseppina E. Grieco ◽  
Guido Sebastiani ◽  
Daniela Fignani ◽  
Noemi Brusco ◽  
Laura Nigi ◽  
...  
Keyword(s):  
Human Plasma ◽  
Rna Sequencing ◽  
High Throughput ◽  
Plasma Samples ◽  
Human Plasma Samples ◽  
Non Coding Rnas

High-Throughput Structural Elucidation of Amides in Mallotus lianus Croiz Plant Materials by LC-ESI-MS-MS

2009 ◽  
Vol 70 (3-4) ◽  
pp. 439-445 ◽  
Author(s):  
Liyan Jiang ◽  
Juanjuan Chen ◽  
Shan He ◽  
Cuirong Sun
Keyword(s):  
High Throughput ◽  
Structural Elucidation ◽  
Plant Materials ◽  
Esi Ms

High-throughput HPLC-MS/MS method to determine ibandronate in human plasma for pharmacokinetic applications

2009 ◽  
Vol 877 (27) ◽  
pp. 3159-3168 ◽  
Author(s):  
Isabela Tarcomnicu ◽  
Mihaela Cristina Gheorghe ◽  
Luigi Silvestro ◽  
Simona Rizea Savu ◽  
Irina Boaru ◽  
...  
Keyword(s):  
Human Plasma ◽  
High Throughput
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