Alanine dehydrogenase and its applications – A review

2019 ◽  
Vol 39 (5) ◽  
pp. 648-664 ◽  
Author(s):  
Ushmaben Chandrakantbhai Dave ◽  
Ravi-Kumar Kadeppagari
Keyword(s):  
Alanine Dehydrogenase

scholarly journals Efficient Amino Donor Recycling in Amination Reactions: Development of a New Alanine Dehydrogenase in Continuous Flow and Dialysis Membrane Reactors

Catalysts ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 520
Author(s):  
David Roura Padrosa ◽  
Zoya Nisar ◽  
Francesca Paradisi
Keyword(s):  
Continuous Flow ◽  
Membrane Reactors ◽  
Dialysis Membrane ◽  
Widespread Application ◽  
Recycling System ◽  
Alanine Dehydrogenase ◽  
Halomonas Elongata ◽  
Amino Donor ◽  
Recycling Systems ◽  
Excellent Stability

Transaminases have arisen as one of the main biocatalysts for amine production but despite their many advantages, their stability is still a concern for widespread application. One of the reasons for their instability is the need to use an excess of the amino donor when trying to synthesise amines with unfavourable equilibria. To circumvent this, recycling systems for the amino donor, such as amino acid dehydrogenases or aldolases, have proved useful to push the equilibria while avoiding high amino donor concentrations. In this work, we report the use of a new alanine dehydrogenase from the halotolerant bacteria Halomonas elongata which exhibits excellent stability to different cosolvents, combined with the well characterised CbFDH as a recycling system of L-alanine for the amination of three model substrates with unfavourable equilibria. In a step forward, the amino donor recycling system has been co-immobilised and used in flow with success as well as re-used as a dialysis enclosed system for the amination of an aromatic aldehyde.

scholarly journals d-Amino Acids as Inducers of l-Alanine Dehydrogenase in Bacillus subtilis

1968 ◽  
Vol 243 (5) ◽  
pp. 1006-1011
Author(s):  
R Berberich ◽  
M Kaback ◽  
E Freese
Keyword(s):  
Amino Acids ◽  
Bacillus Subtilis ◽  
Alanine Dehydrogenase

The substrate specificity of l-alanine dehydrogenase

1961 ◽  
Vol 48 (1) ◽  
pp. 47-55 ◽  
Author(s):  
R.J. O'Connor ◽  
H. Halvorson
Keyword(s):  
Substrate Specificity ◽  
Alanine Dehydrogenase

Metabolic role and regulation of l-alanine dehydrogenase inRhodopseudomonas capsulata

1982 ◽  
Vol 13 (2) ◽  
pp. 155-159 ◽  
Author(s):  
Regina Tolxdorff-Neutzling ◽  
Jobst-Heinrich Klemme
Keyword(s):  
Alanine Dehydrogenase ◽  
Metabolic Role

Alanine dehydrogenase

1993 ◽  
pp. 691-700
Author(s):  
Dietmar Schomburg ◽  
Margit Salzmann ◽  
Dörte Stephan
Keyword(s):  
Alanine Dehydrogenase

A novel type alanine dehydrogenase from Helicobacter aurati: Molecular characterization and application

2020 ◽  
Vol 161 ◽  
pp. 636-642
Author(s):  
Xiaoxiang Hu ◽  
Yajun Bai ◽  
Tai-Ping Fan ◽  
Xiaohui Zheng ◽  
Yujie Cai
Keyword(s):  
Molecular Characterization ◽  
Alanine Dehydrogenase
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