scholarly journals Cellular prion protein gene polymorphisms linked to differential scrapie susceptibility correlate with distinct residue connectivity between secondary structure elements

2020 ◽  
Vol 39 (1) ◽  
pp. 129-139
Author(s):  
Patricia Soto ◽  
India A. Claflin ◽  
Alyssa L. Bursott ◽  
Aimee D. Schwab-McCoy ◽  
Jason C. Bartz
Keyword(s):  
Secondary Structure ◽  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Cellular Prion Protein ◽  
Prion Protein Gene ◽  
Scrapie Susceptibility

scholarly journals Prion protein gene polymorphisms in Turkish native goat breeds

2017 ◽  
Vol 96 (2) ◽  
pp. 299-305 ◽  
Author(s):  
HASAN MEYDAN ◽  
ERKAN PEHLİVAN ◽  
MUSTAFA MUHIP ÖZKAN ◽  
MEHMET ALI YILDIZ ◽  
WILFRED GOLDMANN
Keyword(s):  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Prion Protein Gene

scholarly journals No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population

2006 ◽  
Vol 38 (6) ◽  
pp. 727-731 ◽  
Author(s):  
Kyungsook Ahn ◽  
Eunkyung Kim ◽  
Young-A Kwon ◽  
Doh Kwan Kim ◽  
Jong-Eun Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Korean Population ◽  
Prion Protein Gene

Report of outbreaks of classical scrapie in Dorper sheep and associated prion protein gene polymorphisms in affected flocks

2015 ◽  
Vol 47 (6) ◽  
pp. 1203-1212 ◽  
Author(s):  
Caroline Pinto de Andrade ◽  
Eduardo Conceição de Oliveira ◽  
Juliano Souza Leal ◽  
Laura Lopes de Almeida ◽  
Luiza Amaral de Castro ◽  
...  
Keyword(s):  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Classical Scrapie ◽  
Prion Protein Gene ◽  
Dorper Sheep

Prion protein gene polymorphisms in four goat breeds of Pakistan

2007 ◽  
Vol 36 (1) ◽  
pp. 141-144 ◽  
Author(s):  
M. E. Babar ◽  
M. Abdullah ◽  
A. Nadeem ◽  
A. U. Haq
Keyword(s):  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Prion Protein Gene

Detection of prion protein gene polymorphisms in Baltic breeds of sheep

2006 ◽  
Vol 159 (8) ◽  
pp. 247-250 ◽  
Author(s):  
E. Sild ◽  
R. Volskiene ◽  
I. Viinalass ◽  
I. Miceikiene ◽  
Z. Grislis ◽  
...  
Keyword(s):  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Prion Protein Gene

scholarly journals Prion protein gene polymorphisms in Saccharomyces cerevisiae

2003 ◽  
Vol 49 (4) ◽  
pp. 1005-1017 ◽  
Author(s):  
Catarina G. Resende ◽  
Tiago F. Outeiro ◽  
Laina Sands ◽  
Susan Lindquist ◽  
Mick F. Tuite
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Prion Protein Gene

scholarly journals Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

animal ◽  
2016 ◽  
Vol 10 (10) ◽  
pp. 1585-1593 ◽  
Author(s):  
L. Curcio ◽  
C. Sebastiani ◽  
P. Di Lorenzo ◽  
E. Lasagna ◽  
M. Biagetti
Keyword(s):  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Prion Protein Gene ◽  
Atypical Scrapie

scholarly journals Functional disruption of the prion protein gene in cloned goats

2006 ◽  
Vol 87 (4) ◽  
pp. 1019-1027 ◽  
Author(s):  
Guohua Yu ◽  
Jianquan Chen ◽  
Huiqing Yu ◽  
Siguo Liu ◽  
Juan Chen ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Cellular Prion Protein ◽  
Abnormal Development ◽  
Transmissible Spongiform Encephalopathies ◽  
Membrane Glycoprotein ◽  
Prion Protein Gene ◽  
Spongiform Encephalopathies ◽  
Scrapie Infection ◽  
Large Animals

The cellular prion protein (PrPC), a membrane glycoprotein anchored to the outer surface of neurons, lymphocytes and other cells, is associated directly with the pathogenesis of the transmissible spongiform encephalopathies (TSEs) occurring mainly in humans, cattle, sheep and goats. Although mice lacking PrPC develop and reproduce normally and are resistant to scrapie infection, large animals lacking PrPC, especially those species in which TSE occurs naturally, are currently not available. Here, five live PRNP +/− goats cloned by gene targeting are reported. Detailed RNA-transcription and protein-expression analysis of one PRNP +/− goat showed that one allele of the caprine PRNP gene had been disrupted functionally. No gross abnormal development or behaviour could be seen in these PRNP +/− goats up to at least 3 months of age. These heterozygous PRNP +/− goats are ready to be used in producing homozygous PRNP −/− goats in which no PrPC should be expressed.

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