scholarly journals Structural basis for the inhibition of SARS-CoV2 main protease by Indian medicinal plant-derived antiviral compounds

2020 ◽  
pp. 1-9
Author(s):  
Konda Mani Saravanan ◽  
Haiping Zhang ◽  
Renganathan Senthil ◽  
Kevin Kumar Vijayakumar ◽  
Vignesh Sounderrajan ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Structural Basis ◽  
Indian Medicinal Plant ◽  
Antiviral Compounds ◽  
Main Protease

Application of EPR Spectroscopy to Identify Irradiated Indian Medicinal Plant Products

2012 ◽  
Vol 77 (6) ◽  
pp. C710-C718 ◽  
Author(s):  
Bhaskar Sanyal ◽  
S. Chatterjee ◽  
Prasad S. Variyar ◽  
Arun Sharma
Keyword(s):  
Medicinal Plant ◽  
Epr Spectroscopy ◽  
Indian Medicinal Plant ◽  
Plant Products

Acute and subacute toxicity studies of Aegle marmelos Corr., an Indian medicinal plant

Phytomedicine ◽  
2007 ◽  
Vol 14 (2-3) ◽  
pp. 209-215 ◽  
Author(s):  
A. Veerappan ◽  
S. Miyazaki ◽  
M. Kadarkaraisamy ◽  
D. Ranganathan
Keyword(s):  
Medicinal Plant ◽  
Aegle Marmelos ◽  
Indian Medicinal Plant ◽  
Subacute Toxicity ◽  
Toxicity Studies

scholarly journals Structural Basis of SARS-CoV-2 3CLpro and Anti-COVID-19 Drug Discovery from Medicinal Plants

2020 ◽  
Author(s):  
Muhammad Tahir ul Qamar ◽  
Safar M. Alqahtani ◽  
Mubarak A. Alamri ◽  
Ling-Ling Chen
Keyword(s):  
Life Cycle ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Severe Acute Respiratory Syndrome ◽  
Medicinal Plant ◽  
Homology Model ◽  
Structural Basis ◽  
Health Concerns ◽  
Recent Outbreak ◽  
Drug Discovery Target

The recent outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 in December 2019 raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CLpro) enzyme, which controls coronavirus replication and is essential for its life cycle, is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV. Therefore, herein, we analysed the 3CLpro sequence, constructed a 3D homology model, and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds. Our analyses revealed that the top nine hits may serve as potential anti- SARS-CoV-2 lead molecules for further optimisation and drug development to control COVID-19.

The Indian Medicinal Plant Aegle marmelos in the Treatment of Diabetes Mellitus

2013 ◽  
pp. 519-536
Author(s):  
P.L. Palatty ◽  
A.R. Shivashankara ◽  
M.S. Baliga ◽  
A. Jaiswal ◽  
P. Pankaj ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plant ◽  
Aegle Marmelos ◽  
Indian Medicinal Plant ◽  
Treatment Of Diabetes
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